银杏叶提取物注射液联合脑苷肌肽治疗急性脑梗死的临床研究

目的 探讨银杏叶提取物注射液联合脑苷肌肽注射液治疗急性脑梗死的临床疗效。方法 选取2016年9月—2017年9月在濮阳市安阳地区医院进行治疗的急性脑梗死患者168例为研究对象，所有患者根据治疗方法的差别分为对照组和治疗组，每组各84例。对照组静脉滴注脑苷肌肽注射液，16 mL加入到5%葡萄糖注射液250 mL中，1次/d。治疗组在对照组基础上静脉滴注银杏叶提取物注射液，20 mL加入到5%葡萄糖注射液250 mL中，1次/d。两组均连续治疗2周。观察两组的临床疗效，比较两组的血清学指标、血液流变学指标和美国国立卫生研究院卒中量表（NIHSS）评分。结果 治疗后，对照组和治疗组的总有效率分别为84.52%、97.62%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清人神经胶质纤维酸性蛋白（GFAP）、亲环素A（CyPA）、血小板活化因子（PAF）、单核细胞趋化蛋白-1（MCP-1）、同型半胱氨酸（Hcy）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组红细胞压积（HCT）、全血黏度（WBV）、纤维蛋白原（FIB）、血浆黏度（PV）水平均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组NIHSS评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组NIHSS评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 银杏叶提取物注射液联合脑苷肌肽注射液治疗急性脑梗死具有较好的临床疗效，可改善机体细胞因子水平和血液流变学指标，有利于神经功能恢复，具有一定的临床推广应用价值。

Clinical study on Extract of Ginkgo Biloba Leaves Injection combined with cattle encephalon glycoside and ignotin in treatment of acute cerebral infarction

Objective To investigate the clinical effect of Ginkgo Biloba Leaves Injection combined with Cattle Encephalon Glycoside and Ignotin Injection in treatment of acute cerebral infarction. Methods Patients (168 cases) with acute cerebral infarction in Puyang Anyang District Hospital from September 2016 to September 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 84 cases. Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 16 mL added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group, 20 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes, hemorheological indexes, and NIHSS score in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.52% and 97.62%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of GFAP, CyPA, PAF, MCP-1, and Hcy in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of HCT, WBV, FIB, and PV in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NIHSS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the NIHSS score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Ginkgo Biloba Leaves Injection combined with Cattle Encephalon Glycoside and Ignotin Injection has clinical curative effect in treatment of acute cerebral infarction, can improve cytokine levels and hemorheological indexes, be beneficial to the recovery of nerve function, which has a certain clinical application value.