奎的平与氯丙嗪对精神分裂症患者生活质量的影响

目的 探讨奎的平、氯丙嗪对精神分裂症患者生活质量的影响。方法 符合CCMD-3诊断标准的精神分裂症患者分为奎的平组（30例）与氯丙嗪组（为对照组30例）进行了3个月的临床研究，用PANSS、WHO．QOL-100分别评定患者的精神症状和生活质量。结果 3个月治疗后奎的平组患者PANSS总分和阴性因子分改善优于氯丙嗪组；奎的平对患者生活质量的影响除精神支柱外均有明显提高；氯丙嗪仅能部分提高患者的生活质量，但对患者的生活、心理和独立性领域没有明显改善。结论 奎的平对精神分裂症患者的生活质量的改善优于氯丙嗪。

Effect of Quetiapine and Chlorphrenia on the Life Quality of Patients with Schizophrenia

Objective To studly effect of quetiapine and chlorpromazine on the life quality of patients with schizophrenia. Methods Two groups of patients conforming to the CCMD-- 3 diagnosis standard, with each consisting of 30 persons, were treaeated and studied respectively with quetiapine and chlorpromazine for a period of three months, the mental state and life quality of the two groups were separately evaluated with PANSS and WHO. QOL-- 100. Results Through three months of treatment, the group taking quetiapine acquired bigger improvements in terms of total PANSS score and negative factor scores. Chlorpromazine group had move adverse reactions than quetiapine group. For the quetipine group, all the aspelts of life quality, except for spiritual pillar, were remarkably enhanced, while for the chlorpromazine group, but for partial life quality improvement, there were no notable achievements in the fields of physiology, psychology and independence. Conclusion Quetiapine is superion to chlorpromazine on the quality of life first--opisode schizophrenice.