| 鸭跖草的抗补体活性成分及其作用靶点(英文) |
| |
| 引用本文： | 金家宏,程志红,陈道峰. 鸭跖草的抗补体活性成分及其作用靶点(英文)[J]. 中国药学, 2012, 21(6): 577-581. DOI: 10.5246/jcps.2012.06.073 |
| |
| 作者姓名： | 金家宏 程志红 陈道峰 |
| |
| 作者单位： | 复旦大学药学院生药学教研室 |
| |
| 基金项目： | National Natural Science Foundation for ExcellentYouth (Grant No.30925042);State Key Program for the InnovativeDrugs from the Ministry of Science and Technology (Grant No.2009ZX09502-013 and 2009ZX09301-011) |
| |
| 摘 要： | ![]()
采用抗补体活性导向分离法从中药鸭跖草中分离鉴定了24个化合物, 活性测试结果显示6个化合物对补体系统的经典途径和旁路途径显示出不同程度的抑制作用 (CH500.12-1.44 mM, AP500.28-7.05 mM)。作用靶点研究显示喹诺酸作用于补体系统的C1q, C2, C3, C4, C5 和 C9组分; β-谷甾醇作用于C3 和 C4组分; (+)-儿茶素-3-O-β-D-(2-肉桂酰基)-葡萄糖苷、对甲基苯酚和6-甲氧基-3-甲基-1,2,4-苯三酚均作用于C1q, C2, C3, C5 和C9组分。
|
| 关 键 词： | 鸭跖草 化学成分 补体抑制剂 作用靶点 |
Anti-complement constituents of Commelina communis and their targets in complement activation cascade |
| |
| Jiahong Jin,Zhihong Cheng,Daofeng Chen. Anti-complement constituents of Commelina communis and their targets in complement activation cascade[J]. Journal of Chinese Pharmaceutical Sciences, 2012, 21(6): 577-581. DOI: 10.5246/jcps.2012.06.073 |
| |
| Authors: | Jiahong Jin Zhihong Cheng Daofeng Chen |
| |
| Affiliation: | * Department of Pharmacognosy,School of Pharmacy,Fudan University,Shanghai 201203,China |
| |
| Abstract: | ![]()
|
| |
| Keywords: | Commelina communis Chemical constituents Complement inhibitor Action targets |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国药学》浏览原始摘要信息 |
|
点击此处可从《中国药学》下载免费的PDF全文 |
|
