Pancreatic Extract and the Intestinal Uptake of Vitamin B12 |
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| Authors: | Gerhard Von Der Lippe Knut-Jan Andersen Lars Mörkrid Henning Schjönsby |
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| Affiliation: | Section for Clinical Research, Medical Dept. A, University of Bergen, Haukeland Sykehus, Bergen, Norway |
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| Abstract: | Pancreatic extract (PE) contained small-molecular, thermo-stable as well as macro-molecular, thermo-labile factors capable of reducing the uptake of 57CoB12 bound to rat intrinsic factor by perfused rat intestinal segments (p<0.01 and p<0.01). Neither non-radioactive vitamin B12 nor non-pancreatic protein reduced the 57CoB12-uptake (p>0.5 and p>0.1). Crystalline trypsin and trypsinogen, but not chymotrypsin, also inhibited the uptake (p<0.05, p<0.02 and p>0.05). The tryptic inhibition was abolished by soybean trypsin inhibitor (p>0.05). |
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| Keywords: | Chymotrypsin intestinal secretions pancreatic disease pancreatic extract trypsin trypsin inhibitor trypsinogen vitamin B12 vitamin B12 deficiency |
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