单发脑转移瘤与高级别胶质瘤MR灌注加权成像鉴别诊断

目的：探讨MR灌注加权成像（PWI）在单发脑转移瘤与高级别胶质瘤鉴别诊断中的价值。方法：对单发转移瘤（n=12）或高级别星形细胞瘤（n=22）的MR PWI特征进行回顾性分析。结果：脑PWI中，高级别胶质瘤在对比剂首过后信号强度恢复快速，而转移瘤在对比剂首过后信号回复缓慢且明显不足。高级别胶质瘤与转移瘤的rCBV值无显著差异；但高级别胶质瘤瘤旁及瘤周rCBV值明显高于转移瘤。结论：MR灌注成像能显示肿瘤及瘤周区域血流灌注特性，对单发性脑转移瘤和高级别胶质瘤的鉴别诊断有潜在应用价值。

MR perfusion-weighted imaging in the differentiation of solitary cerebral metastatic tumors and high-grade gliomas

Objective： To determine the value of MR perfusion-weighted imaging （PWI） in the differentiation of solitary cerebral metastatic tumor and high-grade gliomas. Methods： MR PWI features of solitary cerebral metastatic tumors （n=12） or high-grade gliomas （n=22） were compared respectively. Results： After the first pass of contrast agent in PWI, high-grade gliomas demonstrated a rapid recovery of signal intensity; while time-signal-intensity curve （SIC） of metastatic tumors showed a placid and incomplete recovery of signal intensity. There was no significant difference between the rCBV values of highgrade gliomas and metastatic tumors. However, the para- and peri-tumoral rCBV values of high-grade gliomas were significantly higher than that of metastatic tumors. Conclusion： MR perfusion-weighted imaging is a potential tool to differentiate solitary cerebral metastatic tumor from high-grade gliomas by depicting the hemodynamic features of tumors and peritumoral areas.