善得定对预防大鼠腹部手术后肠粘连的研究

目的 评价腹腔注射善得定对大鼠腹部手术后肠粘连的预防作用。方法 将50只SD大鼠随机分为5组：Ⅰ组，对照组；Ⅱ组，腹腔内注射善得定20μg/kg；Ⅲ组，腹腔内注射善得定40μg/kg，腹腔内注射得定60μg/kg；V组，腹腔内注射透明质酸钠。各组动物均于定40μg/kg；Ⅳ组，腹腔内注射善得定60μg/kg；Ⅴ组，腹腔内注射透明质酸钠。各组动物均于术后14d处死，肉眼评价粘连程度，并取粘连的肠段测羟脯氨酸（OHP）。结果 Ⅱ，Ⅲ，Ⅳ，Ⅴ组之粘连程度明显低于Ⅰ组（P＜0．05）；Ⅱ，Ⅲ，Ⅳ组粘连肠段的OHP明显低于I组和V组（P＜0．05）；Ⅱ，Ⅲ，Ⅳ组间粘连程度及粘连肠段的OHP无明显差异（P＞0．05）。结论 腹腔注射善得定对预防腹部手术后肠粘连有一定作用。

Prevention ofpostoperative abdominal adhesions with sandostatin in rats

Objective　To assess the efficacy of sandostatin in preventing postoperative adhesions in rats. Methods　Fifty SD rats were randomly divided into five groups: Group 1, Control group; group 2, sandostatin 20μg/kg intraperitoneal injection (IP); group 3, sandostastin 40μg/kg IP; group 4, sandostatin 60μg/kg IP; group 5, hyaluronate sodium(HA) IP. All animal were killed on the 14th postoperative day. After adhesions were graded according to their severity, adhesive ileal segments were resected for hydroxyproline(OHP) determination. Results　The severity of adhesions in group 2.3.4 and 5 were significantly milder than that in group 1.(P<0.05). The OHP levels of adhensive intestine in group 2.3 and 4 were significantly lower than that in group 1 and 5 (P<0.05).The severity of adhesions and OHP levels in group 2.3 and 4 had no significant difference (P>0.05). Conclusions　Intraperitoneal administration of sandostatin intraoperatively might have some efficacy in preventing adhensions of intestine.