改变力学环境后松质骨胞元结构的预测

松质骨是骨的重要组成部分，结构疏松、多孔，由针状、片状骨小梁组成多种胞体，其结构称为胞元结构。正常生理状态下，骨质的形成与吸收呈平衡态，骨结构稳定，当骨所处的力学环境发生变化时，骨的结构形态也随之变化。松质骨细观结构数值模拟变化的力学环境与骨结构的关系目前未见报道，本文是采用带有生理限定应力的自适应生理模型与有限元相结合的方法，在力学环境发生变化后用计算机预测松质骨胞元结构；定量的研究了松质骨胞元结构从一种优化平衡态到另一种平衡态与其力学环境的关系，模拟了松质骨胞元结构的变化与力学环境的适应性。把这种骨结构预测从宏观水平提高到细观水平。

PREDICTION OF CANCELLOUSCELLULAR STRUCTURE OF BONE AFTER CHANGE OF MECHANICAL ENVIRONMENT

Cancellous bone is an important part of bone, which is porous, made of an interconnecting framework of trabeculae. Its basic makeup are cellular structures. The formation and resorption of bone in adult normally keep balance, and the bone structure remains stable. There is the significance of theory and clinic to predict cancellous structure. The bone structure, however, changes with the variation of the mechanical environment to which it is exposed. Few papers on cancellous structure have been reported in literature. The paper on the relations between the mechanical condition and change of cancellous structure haven′t been reported. In the paper, cancellous cellular structure of bone is predicted using the physiologically controlling model with physiologically limiting stress, integrated with the finite element method. First, by the example of prediction of a sort of cancellous cellular structure bone, the process of prediction using the model is detailedly described. Then, from same cancellous cellular structure as initial structure, the cancellous cellular structures according with different loading conditions are predicted. Finally., from different cancellous cellular structures as initial structures, all cancellous cellular structures predicted under same loading conditions are similar, or almost are regarded as a same cancellous cellular structure. From above, cancellous cellular structure and its change adapt to their respective mechanical environment. We not only quantitatively describe the relation of adaptation tetween the mechanical condition and cancellous cellular structure, but also make the prediction of bone structure develop from macrostructure level to microstructure level.