<Emphasis Type="Italic">TCF7L2</Emphasis>variant genotypes and type 2 diabetes risk in Brazil: significant association,but not a significant tool for risk stratification in the general population |
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| Authors: | GF Marquezine AC Pereira AGP Sousa JG Mill WA Hueb JE Krieger |
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| Institution: | 1.Heart Institute,University of S?o Paulo Medical School,Sao Paulo,Brazil;2.Federal University of Rio Grande do Norte,Natal,Brazil;3.Federal University of Espirito Santo,Vitória,Brazil |
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| Abstract: | Background Genetic polymorphisms of the TCF7L2 gene are strongly associated with large increments in type 2 diabetes risk in different populations worldwide. In this study,
we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction
in the general population. |
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