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| 马钱子生物碱类成分经口给药后在大鼠体内的药动学研究 | |
| 引用本文： | 屈艳格,陈 军,王冬月,蔡宝昌. 马钱子生物碱类成分经口给药后在大鼠体内的药动学研究[J]. 医学教育探索, 2013, 44(8): 1008-1012 |
| 作者姓名： | 屈艳格 陈 军 王冬月 蔡宝昌 |
| 作者单位： | 1.南京中医药大学药学院，江苏 南京 210046 2.江苏省中药炮制重点实验室，江苏 南京 210029 3.南京中医药大学 国家教育部中药炮制规范化及标准化工程研究中心，江苏 南京 210029 4.国家中医药管理局 中药炮制标准重点研究实验室，江苏 南京 210029 5.南京海昌中药集团，江苏 南京 210061 |
| 基金项目： | 国家自然科学基金资助项目（30701111） |
| 摘 要： | 目的 比较马钱子生物碱类成分（马钱子碱、马钱子总生物碱和马钱子优化总生物碱）ig给药后在大鼠体内的药动学过程。方法 大鼠ig给药后取血，以石杉碱甲为内标，HPLC法测定大鼠血浆样品中马钱子碱，DAS 1.0程序拟合房室模型并计算药动学参数。结果 马钱子生物碱类成分ig给药后马钱子碱的药动学行为均符合二室模型；与马钱子碱单体给药相比，马钱子总生物碱与马钱子优化总生物碱能显著增加马钱子碱的体内吸收，其他药动学参数无显著差异。结论 ig给以马钱子生物碱类成分后，马钱子其他生物碱类成分对马钱子碱有吸收促进作用。 |
| 关 键 词： | 马钱子；马钱子碱；马钱子总生物碱；马钱子优化总生物碱；药动学 |
In vivo pharmacokinetics of strychnos alkaloids in rats after ig administration |
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| QU Yan-ge,CHEN Jun,WANG Dong-yue,CAI Bao-chang. In vivo pharmacokinetics of strychnos alkaloids in rats after ig administration[J]. Researches in Medical Education, 2013, 44(8): 1008-1012 | |
| Authors: | QU Yan-ge CHEN Jun WANG Dong-yue CAI Bao-chang |
| Affiliation: | 1.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China 2.Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing 210029, China 3.Engineering Center for Standardization of Chinese Medicine Processing, Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210029, China 4.Key Laboratory for Standardization of Chinese Medicine Processing, State Administration of Traditional Chinese Medicine, Nanjing 210029, China 5.Nanjing Haichang Chinese Medicine Group Corporation, Nanjing 210061, China |
| Abstract: | Objective To evaluate the in vivo pharmacokinetics of strychnos alkaloids [brucine, total alkaloids in Strychni Semen (TASS), and optimal total alkaloids in Strychni Semen (OTASS)] by ig administration to rats. Methods The rats were ig administered with strychnos alkaloids and their blood samples were taken. Huperzine A was used as an internal standard. The brucine in plasma of rats was detected by HPLC method. The compartment model was fitted and the pharmacokinetic parameters were calculated by DAS1.0 program. Results The pharmacokinetic analysis showed that brucine behaved as a two-compartment model in the three solutions after ig administration in rats. Compared with brucine monomer administration, the solution of TASS and OTASS could obviously increase the absorption of brucine in vivo, but other pharmacokinetic parameters had no significant difference. Conclusion After ig administration with strychnos alkaloids, the other alkaloids in Strychni Semen could promote the absorption of brucine. |
| Keywords: | Strychni Semen brucine total alkaloids in Strychni Semen optimal total alkaloids in Strychni Semen pharmacokinetics |
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