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An activation of LC3A‐mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma |
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| Authors: | Kaito Nihira Yasuhiro Miki Shinya Iida Sodai Narumi Katsuhiko Ono Erina Iwabuchi Kazue Ise Kazushige Mori Mikiyoshi Saito Masahito Ebina Ikuro Sato Makoto Maemondo Hisafumi Yamada‐Okabe Takashi Kondo Hironobu Sasano |
| Affiliation: | 1. Department of Pathology, School of Medicine, Tohoku University, , Sendai, Japan;2. CHUGAI Pharmaceutical Co., , Gotemba, Japan;3. Department of Respiratory Medicine, Tohoku Pharmaceutical University Hospital, , Sendai, Japan;4. Department of Pathology, Miyagi Cancer Centre, , Natori, Japan;5. Department of Respiratory Medicine, Miyagi Cancer Centre, , Sendai, Japan;6. Department of Thoracic Surgery, Tohoku University Graduate School of Medicine, , Sendai, Japan |
| Abstract: | |
| Keywords: | autophagy drug resistance EGFR tyrosine kinase inhibitors lung cancer DNA methylation |