| 厄洛替尼治疗老年晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 杨燕霞,毋永娟,华云旗,袁海清. 厄洛替尼治疗老年晚期非小细胞肺癌的临床观察[J]. 中国肺癌杂志, 2009, 12(7). DOI: 10.3779/j.issn.1009-3419.2009.07.009 |
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| 作者姓名： | 杨燕霞 毋永娟 华云旗 袁海清 |
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| 作者单位： | 内蒙古包头市肿瘤医院肿瘤内科一病区,包头,014030 |
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| 摘 要： | 背景与目的 非小细胞肺癌(NSCLC)约占肺癌的80%,其中70%以上为晚期患者.本文评价单药厄洛替尼治疗老年晚期非小细胞的客观疗效及毒副反应.方法 观察29例老年晚期NSCLC,口服厄洛替尼150 mg/d,记录临床疗效及毒副反应,共观察3个月,统计分析结果 .结果 29例患者均可评价疗效,总有效率为20.69%(6/29),其中CR 1例,PR 5例,SD 9例,PD14例.Ⅲ期与Ⅳ期患者有效率比较差异没有统计学意义(P=0.337).毒副反应主要为1-2级毒性反应,包括皮疹(37.93%)、腹泻(17.24%)和呕吐(6.9%).3例患者因严重毒性反应终止厄洛替尼治疗,其中1例患者口服21 d后出现典型肺纤维化.结论 单药厄洛替尼治疗老年NSCLC有较高的临床有效率,患者耐受性尚可,值得临床进一步研究.
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| 关 键 词： | 厄洛替尼 肺肿瘤 化疗 |
Clinical Observation of Erlotinib in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer |
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| Yanxia YANG,Yongjuan WU,Yunqi HUA,Haiqing YUAN. Clinical Observation of Erlotinib in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2009, 12(7). DOI: 10.3779/j.issn.1009-3419.2009.07.009 |
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| Authors: | Yanxia YANG Yongjuan WU Yunqi HUA Haiqing YUAN |
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| Affiliation: | Yanxia YANG,Yongjuan WU,Yunqi HUA,Haiqing YUAN Department of Oncology,Tumor Hospital of Baotou,Baotou 014030,China |
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| Abstract: | Background and objective About 80% lung cancer is non-small cell lung cancer(NSCLC) and more than 70% are in advanced stage.The aim of this study is to evaluate the clinical efficacy and the side effects of erlotinib in the treatment of elderly patients with advanced non-small cell lung cancer.Methods Twenty-nine patients with advanced non-small cell lung cancer were treated with erlotinib 150 mg/d,then the adverse reaction and clinical efficacy were recorded during 3 months.Results Total 29 patients were e... |
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| Keywords: | Erlotinib Lung neoplasms Chemotherapy |
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