| 新型复方含氯消毒剂安全性毒理实验的观察 |
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| 引用本文： | 杨帆,葛莲英,谢裕安,黎远冬,李艳,陆益,梁宁生. 新型复方含氯消毒剂安全性毒理实验的观察[J]. 应用预防医学, 2004, 10(5): 260-261 |
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| 作者姓名： | 杨帆 葛莲英 谢裕安 黎远冬 李艳 陆益 梁宁生 |
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| 作者单位： | 广西壮族自治区肿瘤防治研究所,南宁,530021 |
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| 基金项目： | 广西区科学技术厅资助项目 (桂科攻0332004) |
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| 摘 要： | 目的为确保新型复方含氯消毒剂安全性 ,进行相应的毒理学评价。方法采用小鼠急性经口和吸入毒性试验 ,家兔完整和破损皮肤刺激试验 ,家兔急性眼刺激试验 ,小鼠骨髓嗜多染红细胞微核试验。结果小鼠急性口服LD50>5000mg/kgBW和吸入LC502h>10000mg/m3,消毒剂应用液的5倍浓度对家兔完整和破损皮肤、眼睛均属无刺激性。小鼠骨髓微核试验结果为阴性 ,PCE/NCE>1。结论该消毒剂在一定条件使用对人是安全的
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| 关 键 词： | 急性 复方 含氯消毒剂 小鼠 毒理实验 吸入 观察 家兔 LD50 浓度 |
| 文章编号： | 1007-158X(2004)05-0260-02 |
| 修稿时间： | 2004-06-18 |
Experimental observation on safety of a new compound chlorine-containing disinfectant |
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| YANG Fan,GE Lian-ying,XIE Yu-an et al.Guangxi Cancer Institute,Nanning. Experimental observation on safety of a new compound chlorine-containing disinfectant[J]. Journal of Applied Preventive Medicine, 2004, 10(5): 260-261 |
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| Authors: | YANG Fan GE Lian-ying XIE Yu-an et al.Guangxi Cancer Institute Nanning |
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| Affiliation: | YANG Fan,GE Lian-ying,XIE Yu-an et al.Guangxi Cancer Institute,Nanning530021 |
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| Abstract: | Objective To evaluate the safety of the disinfectant.Methods The acute oral and inhalation toxicity in mice,the skin and eye irritation of the rabbits,and the effect on the micronucleus frequency of bone marrowcells in mice were studied.Results The oral LD 50 and inhalational LC 50 2h among mice were higher than5000mg/kgBW and10000mg/m 3 respectively.There was no skin and eye irritation in rabbits after being contacted to the disinfectant of five time using concentration.The disinfectant had no significant effect on the micronucleus rate of bone marrowcells in mice.PCE/NCE>1.Conclusion The results indicate that the disinfectant is safe for human under certain using condition. |
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| Keywords: | New compound chlorine_containing disinfectant Acute toxicity Irritation Mutation |
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