| 帕金森病血抗氧化酶活性的研究 |
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| 引用本文： | 张本恕,江德华,朱理珩,孙国敏,单书宝,纪志娟,杜深.帕金森病血抗氧化酶活性的研究[J].中国神经精神疾病杂志,1995(3). |
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| 作者姓名： | 张本恕 江德华 朱理珩 孙国敏 单书宝 纪志娟 杜深 |
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| 作者单位： | 天津医科大学总医院神经内科，天津市神经病学研究所神经化学室 |
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| 摘 要： | 本文报道６７例帕金森病（ＰＤ）患者血超氧化物歧化酶（ＳＯＤ）．谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ），过氧化氢酶（ＣＡＴ）活性及脂质过氧化物（ＬＰＯ）量的测定结果。ＰＤ病人ＳＯＤ和ＧＳＨ－Ｐｘ活性高于正常对照组，但ＳＯＤ，ＧＳＨ－Ｐｘ和ＣＡＴ的活性及ＬＰＯ量与病程长短无明显关系，也与是否服用美多巴无关。研究结果提示，抗氧化酶活性的改变可能与ＰＤ病因有关。
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| 关 键 词： | 帕金森病，抗氧化酶，超氧化物歧化酶，谷胱甘肽过氧化物酶 |
Study on the activity of blood antioxidant enzymes in Parkinson's disease |
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| Zhang Benshu,et al..Study on the activity of blood antioxidant enzymes in Parkinson's disease[J].Chinese Journal of Nervous and Mental Diseases,1995(3). |
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| Authors: | Zhang Benshu |
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| Institution: | Zhang Benshu, et al. |
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| Abstract: | The activities of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and catalase(CAT), and the amount of lipid peroxidation(LPO) products were measured in blood from 67 patients with Parkinson's disease(PD) and healthy subjects that were taken as a control. Our data indicated that the activities of SOD and GSH--Px in PD were higher than those in normal control. However, the blood antioxidant enzyme activities and LPO were not correlated to the course of AD and Madopar treatment. It is suggested that the activity of aniioxidant enzymes aught be something related to the etiology of PD. |
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| Keywords: | Parkinson's disease Antioxidant enzyme Superoxide dismutase Glutathione peroxidase |
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