Prospective study on metabolic factors and risk of prostate cancer |
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| Authors: | Christel Häggström MSc Tanja Stocks PhD David Ulmert MD PhD Tone Bjørge MD PhD Hanno Ulmer PhD Göran Hallmans MD PhD Jonas Manjer MD PhD Anders Engeland PhD Gabriele Nagel MD PhD Martin Almqvist MD PhD Randi Selmer PhD Hans Concin MD Steinar Tretli PhD Håkan Jonsson PhD Pär Stattin MD PhD |
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| Affiliation: | 1. Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University Hospital, Ume? University, Ume?, SwedenFax: (011) 46‐90‐125396;2. Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University Hospital, Ume? University, Ume?, Sweden;3. Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark;4. Department of Clinical Sciences, Sk?ne University Hospital, Lund University, Malm?, Sweden;5. Department of Surgery, Urology Service, Memorial Sloan‐Kettering Cancer Center, New York, New York;6. Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway;7. Norwegian Institute of Public Health, Oslo/Bergen, Norway;8. Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria;9. Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University, Ume?, Sweden;10. Department of Plastic Surgery, Sk?ne University Hospital, Lund University, Malm?, Sweden;11. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany;12. Agency for Preventive and Social Medicine, Bregenz, Austria;13. Department of Surgery, Sk?ne University Hospital, Lund University, Malm?, Sweden;14. Cancer Registry of Norway, Institute of Population‐based Cancer Research, Oslo, Norway;15. Department of Radiation Sciences, Oncology Center, Ume? University, Ume?, Sweden |
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| Abstract: | BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer. METHODS: In the Metabolic Syndrome and Cancer Project (Me‐Can), data on body mass index (BMI); blood pressure; and blood levels of glucose, cholesterol, and triglycerides were collected for 289,866 men. Cox proportional hazard models were used to calculate relative risks (RRs) by exposures in quintiles as well as for z scores (with a mean of 0 and a standard deviation of 1) together with a composite sum of scores to assess the combined effect of metabolic factors. RRs were corrected for random errors in measurement. RESULTS: During a mean follow‐up of 12 years, 6673 men were diagnosed with prostate cancer and 961 died of the disease. Men with high levels of glucose and triglycerides were found to have a decreased risk of prostate cancer: top versus bottom quintile of glucose: RR, 0.82 (95% confidence interval [95% CI], 0.62‐1.08; P value for trend = .03) and top versus bottom quintile of triglycerides: RR, 0.88 (95% CI, 0.74‐1.04; P value for trend = .001). High BMI, elevated blood pressure, and a high composite z score were found to be associated with an increased risk of death from prostate cancer: top versus bottom quintile of BMI: RR, 1.36 (95% CI, 1.08‐1.71); systolic blood pressure: RR, 1.62 (95% CI, 1.07‐2.45); and per 1‐unit increase of the composite z score: RR, 1.13 (95% CI, 1.03‐1.25). CONCLUSIONS: The authors found no evidence of an association between high levels of metabolic factors and the risk of prostate cancer, but high BMI, elevated blood pressure, and a composite score of all metabolic factors were associated with an increased risk of death from prostate cancer. Cancer 2012. © 2012 American Cancer Society. |
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| Keywords: | epidemiology metabolic factors prostate cancer metabolic syndrome cohort study body mass index blood pressure |
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