POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project |
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Authors: | Jean Bousquet Toni Dedeu Eve Dupas Jean-Louis Pépin Landry Stephane Zeng Eyindanga Sylvie Arnavielhe Julia Ayache Xavier Basagana Samuel Benveniste Nuria Calves Venturos Hing Kin Chan Mehdi Cheraitia Yves Dauvilliers Judith Garcia-Aymerich Ingrid Jullian-Desayes Chitra Dinesh Daniel Laune Jade Lu Dac Ismael Nujurally Giovanni Pau Robert Picard Xavier Rodo Renaud Tamisier Michael Bewick Nils E. Billo Wienczyslawa Czarlewski Joao Fonseca Ludger Klimek Oliver Pfaar Jean-Marc Bourez |
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Affiliation: | 1.MACVIA-France, Fondation partenariale FMC VIA-LR,Montpellier,France;2.INSERM U 1168, VIMA : Ageing and Chronic Diseases Epidemiological and Public Health Approaches,Villejuif,France;3.Université Versailles St-Quentin-en-Yvelines, UMR-S 1168,Montigny le Bretonneux,France;4.Euforea,Brussels,Belgium;5.Charité,Berlin,Germany;6.CHU Montpellier,Montpellier Cedex 5,France;7.ISGlobal, Centre for Research in Environmental Epidemiology (CREAL),Barcelona,Spain;8.IMIM (Hospital del Mar Research Institute),Barcelona,Spain;9.Universitat Pompeu Fabra (UPF),Barcelona,Spain;10.CIBER Epidemiología y Salud Pública (CIBERESP),Barcelona,Spain;11.Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health,INSERM and UPMC Sorbonne Universités, Medical School Saint Antoine,Paris,France;12.AQuAS,Barcelona,Spain;13.Kyomed INNOV,Montpellier,France;14.Université Grenoble Alpes, Laboratoire HP2, INSERM,Grenoble,France;15.CHU de Grenoble,Grenoble,France;16.Bull SAS,échirolles,France;17.National Center of Expertise in Cognitive Stimulation (CEN STIMCO), Broca Hospital,Paris,France;18.Memory and Cognition Laboratory, Institute of Psychology,Paris Descartes University, Sorbonne Paris Cité,Boulogne Billancourt,France;19.Mines ParisTech CRI - PSL Research University,Fontainebleau,France;20.Direction de la Recherche, Innovation et Valorisation, Université Grenoble Alpes,Grenoble,France;21.Neogia,Paris,France;22.Centre National de Référence Narcolepsie Hypersomnies, Département de Neurologie, H?pital Gui-de-Chauliac Inserm U1061,Unité des Troubles du Sommeil,Montpellier,France;23.LIP6 SU,Paris,France;24.Conseil Général de l’Economie Ministère de l’Economie, de l’Industrie et du Numérique,Paris,France;25.Climate and Health Program and ISGlobal and ICREA,Barcelona,Spain;26.iQ4U Consultants Ltd,London,UK;27.Joensuu,Finland;28.Medical Consulting Czarlewski,Levallois,France;29.Center for Health Technology and Services Research- CINTESIS, Faculdade de Medicina,Universidade do Porto,Porto,Portugal;30.MEDIDA, Lda,Porto,Portugal;31.Center for Rhinology and Allergology,Wiesbaden,Germany;32.Department of Otorhinolaryngology, Head and Neck Surgery,Universit?tsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University,Mannheim,Germany;33.Managing Director, EIT Health France,Paris,France |
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Abstract: | Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted areas in 6 EU countries. Data generated in 2018 will be confirmed in 2019 and extended by the individual prospective assessment of pollution (portable sensor, TLR7) in AR. Sleep apnea patients will be used as a demonstrator of sleep disorder that can be modulated in terms of symptoms and severity by air pollution and AR. The geographic information system GIS will map the results. Consequences on quality of life (EQ-5D), asthma, school, work and sleep will be monitored and disseminated towards the population. The impacts of POLLAR will be (1) to propose novel care pathways integrating pollution, sleep and patients’ literacy, (2) to study sleep consequences of pollution and its impact on frequent chronic diseases, (3) to improve work productivity, (4) to propose the basis for a sentinel network at the EU level for pollution and allergy, (5) to assess the societal implications of the interaction. MASK paper N°32. |
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