| Effects of Estrogen Level on the Function of Vascular Endothelial Cells and Expression of Vascular Cell Adhesion Molecule-1(?) |
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| 引用本文： | 吴赛珠,刘建国,谭家余,周可祥,Gorge D Webb,隗和明,郭志刚. Effects of Estrogen Level on the Function of Vascular Endothelial Cells and Expression of Vascular Cell Adhesion Molecule-1(?)[J]. 岭南心血管病杂志(英文版), 2002, 0(2) |
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| 作者姓名： | 吴赛珠 刘建国 谭家余 周可祥 Gorge D Webb 隗和明 郭志刚 |
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| 摘 要： | ![]()
Objectives To ob-serve the effect of different estrogen levels on the secretory function of vascular endothelial cells of female rats, and study the effect of modulation of estrogen level on the expression of vascular cell adhesion molecule - 1 and the concentration of estrogen receptor in vascular endothelial cells. Methods Radioim-munology was used to measure the serum concentration of endothelin and PGI2, and copper - cadmium reduction was employed to measure the serum content of nitrogen monoxide. Radioligand binding and flowcy-tometry were used to measure the expression of estrogen receptor and vascular cell adhesion molecule (VCAM - 1) of vascular endothelial cells respectively. Results 1. The serum concentration of nitric oxide and PGI2 decreased when the ovaries of female rats were removed. In ovariectomized rats, given estrogen, the concentration rose ( P < 0. 05), but the plasma concentration of endothelin was adverse to it. 2. The concentration of estrogen receptor of vascular endothelial cel
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Effects of Estrogen Level on the Function of Vascular Endothelial Cells and Expression of Vascular Cell Adhesion Molecule-1(?) |
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| Abstract: | ![]()
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| Keywords: | Estrogen Vascular endothelial cell Estrogen receptor Vascular endothelial ad-hesion molecule |
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