| 两种国产盐酸西替利嗪片溶出度比较 |
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| 引用本文： | 费艳秋,曹惠明,王平全.两种国产盐酸西替利嗪片溶出度比较[J].中南药学,2003,1(5):279-280. |
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| 作者姓名： | 费艳秋 曹惠明 王平全 |
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| 作者单位： | 上海第二医科大学附属仁济医院临床药学药理研究室,上海,200001 |
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| 摘 要： | 目的考察盐酸西替利嗪片的体外溶出度,为评价其质量提供参考。方法 采用转篮法测定溶出度,用威布尔(Wcibull)分布模型拟合溶出曲线,并对溶出参数m、T50、Td等采用t检验进行统计分析。结果 两厂家盐酸西替利嗪片的溶出参数无显著性差异(P>0.05)。结论 两国产厂家制剂的溶出度均符合规定。
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| 关 键 词： | 盐酸西替利嗪 溶出度 转篮法 威布尔分布模型 |
| 文章编号： | 1672-2981(2003)05-0279-02 |
Vitro dissolution of 2 domestic cetirizine hydrochloride tablets |
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| Fei Yan qiu,Cao Hui-ming,Wang Ping-quan.Vitro dissolution of 2 domestic cetirizine hydrochloride tablets[J].Central South Pharmacy,2003,1(5):279-280. |
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| Authors: | Fei Yan qiu Cao Hui-ming Wang Ping-quan |
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| Abstract: | OBJECTIVE To evaluate the vitro dissolution of 2 domestic cctirizine hydrochloride tablets. METHODS The basket-stirring method was used to determine the dissolubility of the cetirizine hydrocloride tablets. The Weibull distribution model was adopted in the dissolution eurve. The parameters of m. T50 , Td were analyzed by t test. RESULTS There was no significant difference between the parameters of the 2 domestic tablets (P>0. 05). CONCLUSIONS The vitro dissolution of both the 2 domestic cetirizine hydrochloride tablets was qualified. |
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| Keywords: | cetirizine hydrochloride: dissolution the basket-stirring method: Weibull distribution model |
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