| 家族性肥厚型心肌病家系的HLA分型及其临床意义探讨 |
| |
| 引用本文： | 张之炯 张修斌. 家族性肥厚型心肌病家系的HLA分型及其临床意义探讨[J]. 中国现代医学杂志, 1998, 8(7): 1-3 |
| |
| 作者姓名： | 张之炯 张修斌 |
| |
| 作者单位： | 湖南医科大学附属湘雅医院心内科－心血管研究室(张之炯，张利辉，王文军)，湖南医科大学分子药理研究室(张修武，蒋冬贵) |
| |
| 基金项目： | 本课题为国家自然科学基金资助 |
| |
| 摘 要： | 家族性肥厚型心肌病是常染色体显性遣传病，该文报导家族性肥厚型心肌病（ＦＨＣ）３个家系，并对３个家系中全部成员进行ＨＬＡＤＱＡ１－ＤＱＢ１基因分型，确定其以ＤＱＡ１－ＤＱＢ１单倍型。结果显示３个家系中，每个家系的第Ⅱ代所有患病同胞与第Ⅰ代表病双亲间共有一个相同的ＤＱＡ１－ＤＱＢ１单倍型，而第Ⅱ代未患病同胞则不带有这个单倍型。
|
| 关 键 词： | 家族性肥厚型心肌病，家系HLA单倍型，单倍型 |
The HLA TYPING IN FAMILIES WITH FAMILIAL HYPERTROPHIC CARDIOMYOPATHY AND ITS CLINIC SIGNIFICANCE |
| |
| Zhang Zhijiong,et al.. The HLA TYPING IN FAMILIES WITH FAMILIAL HYPERTROPHIC CARDIOMYOPATHY AND ITS CLINIC SIGNIFICANCE[J]. China Journal of Modern Medicine, 1998, 8(7): 1-3 |
| |
| Authors: | Zhang Zhijiong et al. |
| |
| Affiliation: | Zhang Zhijiong,et al . |
| |
| Abstract: | Familial hypertrophic cardiomyopathy is an idiopathic disorder of the myocardium with an autosomal cominant pattern of inheritance. In this paper three kindreds of familial hypertrophic ardiomyopathy and HLA DQA1 /DGB1 haplotypes in all members of these three kin- dreds were reported. The results show that all affected sibs(second generation)and their affected parent (first generation)share a DQA1/ DQB1 haplotype, and the unaffected sibs do not share it.The members in third generation sharing the same haplotype could be regarded as high risk members who should be clinically followed . |
| |
| Keywords: | Familial hypertrophic cardiomyopathy Kindred HLA Haplotype |
| 本文献已被 CNKI 维普 等数据库收录！ |
