| 刺五加总黄酮对脑缺血大鼠脑组织P38及GAP-43蛋白表达影响的实验研究 |
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| 引用本文： | 石学魁,王雅贤,周晓茵,姬云丽.刺五加总黄酮对脑缺血大鼠脑组织P38及GAP-43蛋白表达影响的实验研究[J].中西医结合心脑血管病杂志,2007,5(3):211-212. |
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| 作者姓名： | 石学魁 王雅贤 周晓茵 姬云丽 |
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| 作者单位： | 1. 牡丹江医学院,157011
2. 黑龙江中医药大学 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目;黑龙江省卫生厅科研项目 |
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| 摘 要： | 目的探讨脑缺血大鼠脑组织P38、GAP-43的变化及刺五加总黄酮的保护作用。方法制作大鼠脑缺血模型，应用免疫组化方法，测定正常对照组、治疗组、正常组P38、GAP-43表达的影响。结果P38和GAP-43的表达水平随再灌注延长而不断上升；在各时间点，治疗组P38和GAP-43的表达水平均高于对照组（P〈0．01）。结论刺五加总黄酮可上调突触素P38、生长相关蛋白GAP-43的表达，具有促进突触再建和增强、完善再建突触效能的作用。
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| 关 键 词： | 脑梗死 急性 刺五加总黄酮 生长相关蛋白 |
| 文章编号： | 1672-1349(2007)03-0211-02 |
| 修稿时间： | 2006年11月6日 |
Expression of Total Flavones of Acanthopanacis Senticosi on Protein P38 and GAP-43 of Brain after Cerebral lschemia in Rats |
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| Shi Xuekui,Wang Yaxian,Zhou Xiaoyin,et al.Expression of Total Flavones of Acanthopanacis Senticosi on Protein P38 and GAP-43 of Brain after Cerebral lschemia in Rats[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2007,5(3):211-212. |
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| Authors: | Shi Xuekui Wang Yaxian Zhou Xiaoyin |
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| Institution: | Mudanjiang 157011 |
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| Abstract: | Objective To explore the change of P38 and GAP-43 in cerebral tissue after acute cerebral infarction in rats and the protection of total flavones of acanthpanacis senticosi.Methods Cerebral ischemia models of rats were establishedat first. The expression of P38 and GAP-43 in normal control group (A), treatment group (B) and model group (C) were detect by immunohistochemical method.Results The expressions of P38 and GAP-43 kept increasing. During each stage, levels of P38 and GAP-43 expression in treatment group were higher than that in control group(P<0.01).Conclusion Total flavones of acanthpanacis senticosi could increase the expressions of P38 and GAP-43, promote synapse reconstruction and enhance the function of reconstructive synapse. |
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| Keywords: | P38 |
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