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| 柠檬酸对大鼠的致畸作用 | |
| 引用本文： | 张幼辰,成志强. 柠檬酸对大鼠的致畸作用[J]. 复旦学报(医学版), 1987, 0(3) |
| 作者姓名： | 张幼辰 成志强 |
| 作者单位： | 上海医科大学公共卫生学院营养与食品卫生学教研室(张幼辰)，上海医科大学公共卫生学院营养与食品卫生学教研室(成志强) |
| 摘 要： | 柠檬酸(1)、(2)、(3)分别由三烷基氧膦(TRPO)萃取法、磷酸三丁酯(TBP)萃取法和钙盐法生产所获产品,其对雌性大鼠经口的LD_(50)分别为8250 mg/kg、12 100 mg/kg、5620mg/kg,均属实际无毒类食品添加剂。本研究结果证明,柠檬酸(1)、(3)对鼠增重、着床数、活胎数、受孕率、胎鼠的身长、体重等均未见不良影响。但阳性对照组(敌枯双,1mg/kg)和柠檬酸(2)组(1/4LD_(50),3025mg/kg)对大鼠均呈明显的致畸作用,仔鼠的畸胎发生率分别为3.9和3.2％。 |
| 关 键 词： | 柠檬酸 食品添加剂 致畸作用 剂量效应关系 半数致死量 |
TERATOGENIC EFFECT OF CITRIC ACID IN RATS |
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| Zhang Youchen,Cheng Zhiqiang. TERATOGENIC EFFECT OF CITRIC ACID IN RATS[J]. Fudan University Journal of Medical Sciences, 1987, 0(3) | |
| Authors: | Zhang Youchen Cheng Zhiqiang |
| Abstract: | Three kinds of food additive citric acid were produced by (1) TRPO, (2) by TBP and (3) by the calcium salt method. Their LD50 were 8250 mg/kg, 12 100 mg/ kg and 6520 mg kg respectively, in female rats when the drug was administered by gayage.The results showed no harmful effects on maternal body weight gain, percentage of implantation, pregnancy rate, or fetal height and body weight.However, teratogenic effects were found in the positive control rats on Dexo and citric acid (2). |
| Keywords: | citric acid food additives teratogenic effects dose-responsa relationship LD50 |
| 本文献已被 CNKI 等数据库收录！ | |