大叶蒟中抗抑郁酰胺类化合物

目的研究胡椒科植物大叶蒟(Piper laetispicum C.DC.)的抗抑郁活性成分。方法用动物实验进行活性跟踪,硅胶柱反复分离、纯化,应用MS,UV,IR,NMR鉴定化合物结构。结果从95％乙醇提取物的乙酸乙酯萃取部位分离得到3个具有抗抑郁活性的酰胺类化合物,分别鉴定为N-isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E,4E-nonadienamide (II), N-isobutyl-7-phenyl-2E,4E-heptadienamide (III)。结论化合物I是新化合物,命名为大叶蒟素(laetispicine ),化合物II和III为首次获得的天然产物。

Antidepressant amides from Piper laetispicum C. DC.

Aim To investigate the antidepressant constituents of Piper laetispicum C. DC. Methods The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity. Results Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E,4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E,4E-heptadienamide (III). Conclusion N-Isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I) is a new compound named as laetispicine. N-Isobutyl-9-phenyl-2E,4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E,4E-heptadienamide (III) were isolated for the first time as natural substance.