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| P-gp和Topo-II在原发性肝癌中的表达及临床意义 | |
| 引用本文： | 陆震,熊茂明,孟翔凌. P-gp和Topo-II在原发性肝癌中的表达及临床意义[J]. 实用肝脏病杂志, 2006, 0(4) |
| 作者姓名： | 陆震 熊茂明 孟翔凌 |
| 作者单位： | 合肥市友好医院普外科，安徽医科大学第一附属医院普外科，安徽医科大学第一附属医院普外科 230022 |
| 摘 要： | 目的研究多药耐药相关蛋白P-糖蛋白(gp)和拓扑异构酶II(Topo-II)在原发性肝癌组织中的表达及临床意义。方法采用免疫组化S-P法检测49例原发性肝癌组织P-gp和Topo-II的表达。结果P-gp和Topo-II在原发性肝癌中阳性表达率分别为61.22%(30/49)和32.65%(16/49),P-gp主要在细胞膜和细胞浆中表达,Topo-II在细胞核内表达,P-gp和Topo-II表达与Edmonson分级有关,Topo-II还与转移有关。P-gp、Topo-II在原发性肝癌中表达呈负相关(P<0.05)。结论肝癌组织P-gp和Topo-II表达可能是肝癌对化疗不敏感的原因之一。 |
| 关 键 词： | 肝细胞癌 P-糖蛋白 拓扑异构酶Ⅱ 多药耐药 |
Expression and implication of P-gp and Topo-II in hepatocellular carcinoma. |
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| LU Zhen,XIONG Maoming,MENG Xianglin. Expression and implication of P-gp and Topo-II in hepatocellular carcinoma.[J]. Journal of Clinical Hepatology, 2006, 0(4) | |
| Authors: | LU Zhen XIONG Maoming MENG Xianglin |
| Affiliation: | LU Zhen,XIONG Maoming,MENG Xianglin.Department of General Surgery,First Affiliated Hospital,Anhui Medical University,Hefei 230022,China |
| Abstract: | Objective To investigate the expressions of P-gp and Topo-II in hepatocellular carcinoma(HCC) and analyze its clinical significance.Methods Forty nine histologically verifled HCC specimens were examined for P-gp and Topo-II by immunohistochemical method(sp).Results The positive rates of P-gp and Topo-II were 61.22%(30/49) and 32.65%(16/49),respectively.P-gp was expressed mainly in cytoplasmic membrane and cytoplasm and Topo-II was restricted to cellular nucleus.The expressions of P-gp and Topo-II had relations to histological grade.The expression of Topo-II was also related to metastasis.The expressions of P-gp was inversely related to those of Top-II in HCC(P<(0.05)).Conclusion The expression of P-gp and Topo-II in hepatocelluar carcinoma plays an important role in chemotherapy strategy. |
| Keywords: | Hepatoma P-glycoprotein Topoisomerases-II Multidrug resistance |
| 本文献已被 CNKI 等数据库收录！ | |