| 6,8-二-三氟甲基-7-乙酰氧基白杨素抑制人宫颈癌裸鼠移植瘤生长 |
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| 引用本文： | 宋轶钦,陈忠东.6,8-二-三氟甲基-7-乙酰氧基白杨素抑制人宫颈癌裸鼠移植瘤生长[J].湖南师范大学学报(医学版),2007,4(1):29-32. |
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| 作者姓名： | 宋轶钦 陈忠东 |
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| 作者单位： | 南华大学第一附属医院妇产科,湖南,衡阳,421001 |
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| 摘 要： | 目的:研究6,8-二-三氟甲基-7-乙酰氧基白杨素(dFMAChR)的抗宫颈癌作用。方法:体外培养人宫颈癌(HeLa)细胞,采用MTT比色法测定不同浓度dFMAChR作用72 h对HeLa细胞增殖相对抑制率;建立人宫颈癌裸鼠移植瘤模型,评价dFMAChR在体人宫颈癌治疗的有效性。结果:MTT法测定结果显示,dFMAChR抑制体外培养HeLa细胞生长,呈浓度依赖性。人宫颈癌裸鼠移植瘤模型治疗实验结果表明,dFMAChR对人宫颈癌裸鼠移植瘤的生长具有抑制作用,呈剂量和时间依赖性。结论:dFMAChR能抑制人宫颈癌裸鼠移植瘤生长。
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| 关 键 词： | 宫颈癌 白杨素 白杨素衍生物 治疗作用 |
| 文章编号： | 1673-016x(2007)01-0029-04 |
Inhibition of the Growth of Human Cervical Cancer Xenograft in Nude Mice by 6,8-ditrifluoromethy -7-acetoychrysin,a Novel Chrysin Derivative |
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| SONG Yi-qin,CHEN Zhong-dong.Inhibition of the Growth of Human Cervical Cancer Xenograft in Nude Mice by 6,8-ditrifluoromethy -7-acetoychrysin,a Novel Chrysin Derivative[J].Journal of Hunan Normal University(Medical Science),2007,4(1):29-32. |
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| Authors: | SONG Yi-qin CHEN Zhong-dong |
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| Abstract: | Objective To investigate the therapeutic effect of 6,8ditrifluoromethy-7-acetoychrysin(dFMAChR) on human cervical cancer.Methods The growth inhibitory effect of human cervical cancer line HeLa by treatment with various concentrations of dFMAChR for 72 h were determined using MTT assay.To establish human cervical carcinoma xenograft in nude mouse model,the anti-cervical cancer effect of dFMAChR in vivo were observed.Results MTT assays in vitro showed dFMAChR inhibited significantly the growth of HeLa cells in a concentration-dependent. Therapeutic trial of human cervical carcinoma xenograft in nude mouse model indicated that dFMAChR significantly inhibited the growth of human cervical carcinoma xenografts in Balb/c-nu mice in a dose-and time-dependent manner.Conclusion dFMAChR suppresse the growth of human cervical carcinoma xenografts in Balb/c-nu mice. |
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| Keywords: | cervical cancer chrysinL chrysin derivative therapeutic action |
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