高血压患者血清瘦素、抵抗素水平与颈动脉内膜-中层厚度的关系

目的:探讨原发性高血压患者血清瘦素、抵抗素水平的变化及与颈动脉粥样硬化的相关关系.方法:入选80例原发性高血压患者(病例组),另选32例健康对照者.采用酶联免疫吸附法检测血清瘦素、抵抗素水平;采用彩色超声诊断仪测定颈动脉内膜-中层厚度(IMT).结果:病例组的瘦素(t=-2.530,P=0.013)和抵抗素水平(t=-2.077,P=0.041)均高于对照组.病例组的颈动脉IMT(t=-3.115,P=0.003)和颈动脉最大IMT(t=-3.271,P=0.002)均大于对照组.Pearson相关分析示,高血压患者血清瘦素与IMT(r=0.311,P=0.012)和最大IMT(r=0.308,P=0.013)呈显著正相关;血清抵抗素与IMT(r=0.335,P=0.006)和最大IMT(r=0.284,P=0.022)呈显著正相关.结论:原发性高血压患者的血清瘦素、抵抗素水平显著升高,且它们和颈动脉IMT存在相关性.

Association between serum leptin, resistin and carotid intima media thickness in essential hypertension patients

Objective:To study the relationship between serum leptin, resistin and carotid intima media thickness in patients with essential hypertension.Method:Serum leptin, resistin concentration were measured by enzyme linked immunosorbent assay in 80 cases with essential hypertension,and 32 normal control.Meanwhile, carotid intima media thickness were measured by ultrasonography in all subjects.Result:Serum leptin、resistin were significantly higher in the hypertension group than the control group (t=-2.530,Pleptin=0.013;t=-2.077,Presistin=0.041). Carotid intima media thickness (IMT) was significantly higher in the hypertension group than the control group( t=-3.115,PIMT=0.003;t=-3.271,Pmaximum IMT=0.002).Leptin levels were associated with the carotid IMT (carotid IMT:r=0.311,P=0.012 and maximum carotid IMT:r=0.308,P=0.013) in essential hypertension patients;resistin levels were also associated with the carotid IMT (carotid IMT:r=0.335,P=0.006 and maximum carotid IMT:r=0.284,P=0.022) in essential hypertension patients.Conclusion:Serum leptin、resistin were significantly higher in the hypertension patients;serum leptin、resistin are associated with increasing carotid IMT in essential hypertensive patients respectively.