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GLUT1 gene is a potential hypoxic marker in colorectal cancer patients
Authors:Fu-Yen Chung   Ming-Yii Huang   Ching-Sheng Yeh   Hui-Jen Chang   Tian-Lu Cheng   Li-Chen Yen   Jaw-Yuan Wang  Shiu-Ru Lin
Affiliation:(1) Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China;(2) Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China;(3) Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China;(4) Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China;(5) Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China;(6) Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China;(7) Bio-medical Technology Developmental Center, Fooyin University, Kaohsiung Hsien, Taiwan, Republic of China;(8) Department of Medical Technology, School of Medical and Health Sciences, Fooyin University, Kaohsiung Hsien, Taiwan, Republic of China;(9) Department of Medical Research, Fooyin University Hospital, Ping-Tung Hsien, Taiwan, Republic of China
Abstract:

Background  

Tumor hypoxia is an important factor related to tumor resistance to radiotherapy and chemotherapy. This study investigated molecules synthesized in colorectal cancer cells during hypoxia to explore the possibility of developing molecular probes capable of detecting cell death and/or the efficiency of radiotherapy and chemotherapy.
Keywords:
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