阿魏酸钠和阿斯匹林联用对大鼠血小板聚集的影响及对PGI2-TXA2平衡的调节

单独给大鼠口服阈下剂量的阿魏酸钠(SF)或阿斯匹林(ASA)对胶原诱导的血小板聚集及对颈动脉壁PGI₂样物质的释放均无明显作用。两药并用后大鼠血小板聚集及血小板TXA:样物质的释放均显著地受到抑制,动脉壁PGI₂样物质的释放则无明显变化。说明SF与小剂量ASA联用可增强抗血小板作用。

EFFECTS OF SODIUM FERULATE COMBINED WITH ACETYLSALICYLIC ACID ON RAT PLATELET AGGREGATION AND ON MODULATION OF PGI2-TXA2 BALANCE

Sodium ferulate is one of the constituents of Dang-Gui (Angelica sinensis). In this paper platelet aggregation was measured by turbidimetric method. TXA₂ activity was estimated by measuring the contraction of rabbit thoracic aorta and PGI₂ activity by measuring inhibition of platelet aggregation induced by ADP.Results indicate that neither platelet aggregation nor carotid arterial PGI₂-1ike substance release was affected by oral adminstration of a subthreshold dose of sodium ferulate(300 mg/kg) or a subthreshold dose of acetylsalicylic acid(10mg/kg). However, sodium ferulate in combination with acetylsalicylic acid at the same doses was shown to inhibit platelet aggregation and TXA₂-like substance release (induced by collagen) by 65% and 84%, respectively, while the production of arterial PGI₂-like substance remained unchanged.These results indicate that the combined treatment with these two drugs can potentiate the antiplatelet effects without inhibiting arterial PGI₂-1ike substance release. These data may be of value for the treatment of thrombo-embolic diseases.