| 重度蒸汽吸入性损伤犬伤后肿瘤坏死因子水平的改变及其意义 |
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| 引用本文： | 熊龙,郭光华,李国辉,曹勇,王年云,王文,刘德伍. 重度蒸汽吸入性损伤犬伤后肿瘤坏死因子水平的改变及其意义[J]. 江西医学院学报, 2000, 40(4): 129-131 |
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| 作者姓名： | 熊龙 郭光华 李国辉 曹勇 王年云 王文 刘德伍 |
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| 作者单位： | 熊龙（江西医学院第一附属医院烧伤中心江西南昌 330006）;郭光华（江西医学院第一附属医院烧伤中心江西南昌 330006）;李国辉（江西医学院第一附属医院烧伤中心江西南昌 330006）;曹勇（江西医学院第一附属医院烧伤中心江西南昌 330006）;王年云（江西医学院第一附属医院烧伤中心江西南昌 330006）;王文（江西医学院第一附属医院烧伤中心江西南昌 330006）;刘德伍（江西医学院第一附属医院烧伤中心江西南昌 330006） |
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| 基金项目： | 国家自然科学基金资助项目和江西省主要学科跨世纪学术和技术带头人培养计划 |
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| 摘 要： | 目的研究蒸汽吸人性损伤犬伤后血浆肿瘤坏死因子水平的改变及其与吸入性损伤呼吸循环功能受损程度的关系.方法取犬15条,以蒸汽致重度吸入性损伤,分别于伤前、伤后1h、2h、3h、4h观察有呼气相气道阻力(RE)、心率(HR)、心输出量(CO)、动脉血氧分压(PaO2)、血浆TNF水平;伤后4h致死动物,取肺做病理检查.结果伤后1hTNF、RE升高,HR、CO、PaO2下降;TNF与RE正相关(r=O.965,P
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| 关 键 词： | 肿瘤坏死因子 呼吸功能 循环功能 吸入性损伤 |
| 文章编号： | 100-2294(2000)04-0129-03 |
| 修稿时间： | 2000-09-28 |
Changes in the Level of Tumour Necrosis Factor in Dogs after Severe Steam Inhalation Injury |
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| XIONG Long,GUO Guang hua,LI GUO_hui,CAO Yong,WANG Nian_yun,WANG Wen,LIU De_wu. Changes in the Level of Tumour Necrosis Factor in Dogs after Severe Steam Inhalation Injury[J]. Acta Academiae Medicinae Jiangxi, 2000, 40(4): 129-131 |
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| Authors: | XIONG Long GUO Guang hua LI GUO_hui CAO Yong WANG Nian_yun WANG Wen LIU De_wu |
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| Abstract: | Objective: To investigate the change in the level of tumour necrosis factor (TNF) in blood and its relationship to the degree of damage of cardiopulmonary function in dogs after severe steam inhalation injury. Method: Fifteen dogs were severely injured with steam inhalation. The exspiratory resistance (R E),heart rate (HR),cardial output (CO),arterial oxygen tension (PaO 2) and level of TNF in blood were measured before and 1 h,2 h,3 h,4 h after injury,then all the dog were killed for histopathological examination of their lungs. Results: At 1 hour after injury,the TNF,R E increased,HR,CO,PaO 2 decreased. The level of TNF was positively correlated with R E (r=0.965,P<0.01),and negatively correlated with CO (r=-0.824,P<0.05). Conclusion: Severe steam inhalation injury stimulates secretion of TNF. This is an important factor inducing functional disturbance of cardiopulmonary system,even of the whole body. |
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| Keywords: | tumour necrosis factor cardiopulmonary function steam inhalation doL |
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