类风湿关节炎患者血清中表皮生长因子水平的变化及其临床意义

 目的检测类风湿关节炎（RA）患者血清中表皮生长因子（EGF）水平的变化，探讨EGF 在RA 发病过程中可能存在的意
义。方法选取符合1987 年美国风湿病学会（ACR）修订的RA分类标准的RA 患者38 例，另外选择30例健康人做对照。用
酶联免疫吸附试验（ELISA）测定RA 患者及对照组血清中EGF水平。同时测定RA 患者的类风湿因子（RF）、红细胞沉降率
（ESR）和C 反应蛋白（CRP）。用统计学分析EGF 在各组血清中的变化及其与临床各项指标间的相关性。结果RA组与正常对
照组相比，血清EGF水平显著升高（P < 0.05）。骨质破坏组与单纯骨质疏松组相比，血清EGF水平显著升高（P < 0.05）。RA组
EGF 水平的变化与RF，ESR，CRP水平的变化无显著相关性（P > 0.05）。结论RA 患者血清EGF 水平明显升高，在骨质破坏
组尤为明显。提示EGF 可能部分地参与RA的发病过程。

Serum Epidermal Growth Factor Level Changes and Its Clinical Significance in Patients with Rheumatoid Arthritis

Objective To detect the serum levels of epidermal growth factor（EGF）in rheumatoid arthritis（RA）patients，and explore the
possible role of EGF in RA. Methods The serum level of EGF was measured by enzyme-linked immunosorbent assay（ELISA）in 38 RA
patients diagnosed according to dianostic criteria for RA by American Rheumatism Association and 20 healthy controls. Rheumatoid factor
（RF），erythrocyte sedimentation rate（ESR）and C-creative protein（CRP）were also measured in these 38 RA patients. The relation beween
the serum level changes of EGF and the corresponding clinical indexes in the two groups was statistically analyzed. Results Compared with
the healthy individuals，the serum EGF levels of RA patients increased significantly （P < 0.05）. Compared with simple bone rarefaction pa-
tients，the serum levels of EGF increased significantly in the bone erosion patients（P < 0.05）. The serum levels of EGF in RA patients had
no correlation with RF，ESR and CRP levels（P > 0.05）. Conclusion The evident increase of serum EGF level in RA patients，especially
in bone erosion patients，suggests that EGF may partly play a role in the pathogenesis of RA.