不同BMI的2型糖尿病患者心血管等靶器官功能损伤的风险评估

目的 探讨不同体质量指数(BMI)的2型糖尿病患者心血管等靶器官功能损伤的风险.方法 自2014年1月至2016年1月前瞻性收集该院收治的2型糖尿病患者126例,其中研究组(BMI≥25 kg/m2)57例,对照组(18.5 kg/m2≤BMI＜25kg/m2)69例.分析两组患者的临床特征,并分析BMI与靶器官损伤相关指标[颈动脉内膜中膜厚度(IMT)、动脉硬化指数、冠心病指数和肾小球滤过率]的相关性.结果 两组患者空腹血糖差异无统计学意义(P=0.953),研究组患者BMI显著高于对照组(P=0.000).与对照组比较,研究组患者年龄显著增加(P=0.038);收缩压显著增加(P=0.000);糖尿病家族史显著增加(P=0.000);总胆固醇显著增加(P=0.012);三酰甘油显著增加(P=0.000);高密度脂蛋白显著降低(P=0.003);HOMA-IR水平显著升高(P=0.000);HOMA-β水平显著降低(P=0.000);IMT水平显著升高(P=0.000);动脉硬化指数显著升高(P=0.000);冠心病指数显著升高(P=0.001);肾小球滤过率显著降低(P=0.000).Pearson直线相关分析显示BMI与IMT、动脉硬化指数、冠心病指数和肾小球滤过率相关,r值分别为0.234、0.257、0.294和0.211(均P=0.000).结论 2型糖尿病患者BMI水平与心血管和肾功能损伤有关.

Risk assessment of cardiovascular and other target organs damage in patients with type 2 diabetes and different body mass indexes

Objective To investigate the risk of cardiovascular and other target organs damage in the patients with type 2 di abetes mellitus(T2DM) and different body mass indexes (BMI).Methods One hundred and twenty-six patients with T2DM admitted to our hospital from January 2014 to January 2016were prospectively collected,including 57 cases in the study group (BMI≥25 kg/m2) and 69 cases in the control group (18.5 kg/m2≤BMI＜25 kg/m2).The clinical featuresof the two groups were analyzed,and the correlation between BMI and related indexes of target organ damage [carotid arte ry intima media thickness (IMT),arterial stiffness index,coronary heart disease index and glomerular filtration rate] were analyzed.Results There was no statistically significant difference in fasting blood glucose between the two groups (P=0.953),BMI in the study group was significantly higher than that in the control group (P=0.000).When compared with the.control group,the study group showed a significantly increase in age (P=0.038);a significant increase in systolic blood pressure (P=0.000);a significantly increase in diabetic family history (P=0.000);a significant increase in total cholesterol (P=0.012);a significant increase in triglycerides (P=0.000);a significant decrease in high density lipoprotein (P=0.003);a significant increase in HOMA-IR level (P =0.000);a significant decrease in HOMA-β level (P=0.000);a significant increase in IMT level (P=0.000);a significant increasein arterial stiffness index (P=0.000);a significant increase in coronary heart disease index (P:0.001);and a significant decrease in glomerular filtration rate (P=0.000).The Pearson linear correlation analysis showed that BMI was correlated with IMT,atherosclerosis index,coronary heart disease index and glomerular filtration rate,the r values were 0.234,0.257,0.294 and 0.211 respectively(all P=0.000).Conclusion The BMI level in the patients with T2DM is related to cardiovascular and renal function damage.