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Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients |
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| Authors: | Yvette A. H. Matser Matty L. Terpstra Silvio Nadalin George D. Nossent Jan de Boer Barbara C. van Bemmel Susanne van Eeden Klemens Budde Susanne Brakemeier Frederike J. Bemelman |
| Affiliation: | 1. VU University Medical Center, Amsterdam, The Netherlands;2. Department of Nephrology, Academic Medical Centre, Amsterdam, The Netherlands;3. Department of General, Visceral and Transplantation Surgery, University of Tübingen, Tübingen, Germany;4. Department of Lung Transplantation, University Medical Center Groningen, Groningen, The Netherlands;5. Eurotransplant, International Foundation, Leiden, The Netherlands;6. Department of Pathology, Martini Hospital, Groningen, The Netherlands;7. Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands;8. Department of Nephrology and Medical Intensive Care, Charité ‐ Universit?tsmedizin Berlin, Berlin, Germany |
| Abstract: | We report 4 cases of breast cancer transmission to transplant recipients from a single organ donor that occurred years after donation. The diagnosis of breast cancer was occult at the time of donation. All of the recipients developed a histologically similar type of breast cancer within 16 months to 6 years after transplantation. Three out of 4 recipients died as a result of widely metastasized disease. One of the recipients survived after transplant nephrectomy followed by cessation of immunosuppression and chemotherapy. This extraordinary case points out the often fatal consequences of donor‐derived breast cancer and suggests that removal of the donor organ and restoration of immunity can induce complete remission. |
| Keywords: | clinical decision‐making clinical research/practice complication: malignant donors and donation: deceased organ transplantation in general |