表皮生长因子、雄激素受体和表皮生长因子受体在肝癌组织中的表达及影响因素分析

目的探讨肝癌患者肝癌组织中的表皮生长因子(EGF)、雄激素受体(AR)、表皮生长因子受体(EGFR)的表达情况及临床意义。方法采用免疫组织化学染色法检测EGF、AR、EGFR在90例肝癌患者的肝癌组织和90例非肝癌患者的非肝癌组织中的表达情况,比较不同临床特征肝癌患者肝癌组织中EGF、AR、EGFR的表达情况,分析肝癌患者肝癌组织中EGF、AR、EGFR表达的影响因素。结果肝癌组织中的EGF、AR、EGFR的阳性表达率均明显高于非肝癌组织,差异均有统计学意义(P﹤0.01)。有肝炎史、Ⅲ+Ⅳ期、中低分化、有淋巴结转移的肝癌患者肝癌组织中EGF、AR、EGFR的阳性表达率均高于无肝炎史、Ⅰ+Ⅱ期、高分化、无淋巴结转移的肝癌患者,差异均有统计学意义(P﹤0.05);不同年龄、性别、肿瘤直径的肝癌患者肝癌组织中EGF、AR、EGFR的阳性表达率比较,差异均无统计学意义(P﹥0.05)。Logistic回归分析结果显示,有淋巴结转移、TNM分期为Ⅲ+Ⅳ期是肝癌患者肝癌组织中EGF、AR、EGFR表达的独立危险因素。结论EGF、AR、EGFR在肝癌患者的肝癌组织中呈高表达,且其表达与肝癌患者的淋巴结转移情况和TNM分期密切相关。

Expression of epidermal growth factor,androgen receptor and epidermal growth factor receptor in liver cancer and analysis of influencing factors

Objective To investigate the expression of epidermal growth factor(EGF),androgen receptor(AR)and epidermal growth factor receptor(EGFR)in patients with liver cancer,and to analyze the clinical significance.Method Ninety patients with liver cancer and 90 cases without liver cancer were retrospectively analyzed,the EGF,AR,and EGFR expression in the liver cancer group and non-liver cancer group were detected immunohistochemically,besides,the expressions of EGF,AR and EGFR in liver cancer patients with different clinical pathological features were compared,and the factors affecting the expression of EGF,AR and EGFR in liver cancer tissues were analyzed.Result The positive expression rates of EGF,AR and EGFR in liver cancer tissues were significantly higher than those in non-liver cancer tissues,the difference was statistically significant(P<0.01).Prior history of hepatitis,TNM stage III+IV,moderate to poor differentiation and presence of lymph node metastasis were associated with higher positive expression rate of EGF,AR and EGFR compared with those without hepatitis history,TNM stage I+II,high differentiation and no lymph node metastasis in liver cancer patients(P<0.05);there was no significant difference in relation to the expression of EGF,AR and EGFR in liver cancer patients of different age,gender or tumor diameter(P>0.05).Logistic regression analysis indicated that,lymph node metastasis andTNM stage III+IV were independent factors affecting EGF,AR,EGFR expression in liver cancer tissues of liver cancer patients.Conclusion EGF,AR and EGFR are highly expressed in patients with liver cancer,and their expression are closely related to lymph node metastasis and TNM staging.