首页 | 本学科首页   官方微博 | 高级检索  
     


Randomized trial - oxybutynin for treatment of persistent plantar hyperhidrosis in women after sympathectomy
Authors:Altair da Silva Costa  Jr.   Luiz Eduardo Villa?a Le?o  José Ernesto Succi  Joao Aléssio Juliano Perfeito  Adauto Castelo Filho  Erika Rymkiewicz  Marco Aurelio Marchetti Filho
Affiliation:IFederal University of São Paulo, Paulista School of Medicine, Department of Thoracic Surgery, São Paulo/SP, Brazil;IIFederal University of São Paulo, Paulista School of Medicine, Department of Infectious Diseases, São Paulo/SP, Brazil
Abstract:

OBJECTIVE:

Hyperhidrosis is a common disease, and thoracoscopic sympathectomy improves its symptoms in up to 95% of cases. Unfortunately, after surgery, plantar hyperhidrosis may remain in 50% of patients, and compensatory sweating may be observed in 70%. This clinical scenario remains a challenge. Our objective was to evaluate the effectiveness of oxybutynin in the treatment of persistent plantar hyperhidrosis and compensatory sweating and its effects on quality of life in women after thoracoscopic sympathectomy.

METHOD:

We conducted a prospective, randomized study to compare the effects of oxybutynin at 10 mg daily and placebo in women with persistent plantar hyperhidrosis. The assessment was performed using a quality-of-life questionnaire for hyperhidrosis and sweating measurement with a device for quantifying transepidermal water loss. Clinicaltrials.gov: NCT01328015.

RESULTS:

Sixteen patients were included in each group (placebo and oxybutynin). There were no significant differences between the groups prior to treatment. After oxybutynin treatment, there was a decrease in symptoms and clinical improvement based on the quality-of-life questionnaire (before treatment, 40.4 vs. after treatment, 17.5; p = 0.001). The placebo group showed modest improvement (p = 0.09). The outcomes of the transepidermal water loss measurements in the placebo group showed no differences (p = 0.95), whereas the oxybutynin group revealed a significant decrease (p = 0.001). The most common side effect was dry mouth (100% in the oxybutynin group vs. 43.8% in the placebo group; p = 0.001).

CONCLUSION:

Oxybutynin was effective in the treatment of persistent plantar hyperhidrosis, resulting in a better quality of life in women who had undergone thoracoscopic sympathectomy.
Keywords:Hyperhidrosis   Thoracic Surgery   Oxybutynin
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号