慢性阻塞性肺疾病急性加重期生物标志物的研究进展

C O PD是患病率和病死率居高不下的常见病、多发病，严重影响患者的劳动力和生活质量，也造成了巨大的社会、经济负担。而COPD急性加重（AECOPD）不仅加速疾病进展、进一步降低患者活动耐量，更增加了住院率及病死率，因而近年来开展了大量围绕 A EC O PD生物标志物的研究。本文将从外周血、痰液（包括诱导痰）、呼出气、呼出气冷凝液、BALF、支气管黏膜活检这6个方面分类对近年来A EC O PD生物标志物的研究进展作一综述。

Progress of biomarkers in acute exacerbation of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease ( COPD) is a major cause of chronic morbidity and mortality throughout the world .It not only has a great impact on the patients′ work and quality of life ,but also creates an enormous social and economic burden .Furthermore ,acute exacerbation of COPD ( AECOPD) accelerates the progression of the disease and increases the rates of hospitalizations and deaths .For this reason ,lots of studies have been done in regard to biomarkers of AECOPD during recent years .This review summarizes the research progress of biomarkers in the aspects of blood ,sputum ( including induced sputum) ,exhaled nitric oxide ,exhaled breath condensate ,bronchoalveolar lavage fluid and bronchial biopsies .