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| 术前D二聚体水平可以预测非小细胞肺癌患者术后1年内预后不良 | |
| 引用本文： | Wang Z,Fu J,Diao D,Dang C. 术前D二聚体水平可以预测非小细胞肺癌患者术后1年内预后不良[J]. 中国肺癌杂志, 2011, 14(6): 534-537. DOI: 10.3779/j.issn.1009-3419.2011.06.10 |
| 作者姓名： | Wang Z Fu J Diao D Dang C |
| 作者单位： | 1. 西安交通大学第一附属医院胸外科,西安,710061 2. 西安交通大学第一附属医院肿瘤外科,西安,710061 |
| 摘 要： | 背景与目的部分非小细胞肺癌(non-small cell lung cancer,NSCLC)患者术后短期即出现转移。D二聚体(D-dimer,DD)是肺癌(主要是非手术)患者的预后因素。本研究旨在探讨其能否预测NSCLC患者术后短期预后不良。方法检测56例NSCLC患者的术前DD水平,术后随访1年,终点是出现预后不良事件(转移、局部复发或肺癌相关性死亡)。统计分析组间不良预后对比情况。结果以术前DD水平的中位数(四分位间距)1.05(0.55)mg/L为分界值,高DD组患者中出现预后不良事件11例,而低DD组中出现预后不良事件3例,两组相比具有统计学差异(P=0.03,OR=4.89,95%CI:1.2-20.1)。高DD组与低DD组的疾病进展情况亦有统计学差异(P=0.024)。术前DD对于早期NSCLC(I期、II期),特别是早期腺癌术后短期预后不良的预测最为准确。结论术前DD水平可以预测NSCLC患者术后1年内预后不良,有助于筛选适合手术的患者。 |
| 关 键 词： | 肺肿瘤 D二聚体 预后 |
Pre-operative plasma D-dimer level may predict the poor prognosis within one year after the surgery for non-small cell lung cancer |
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| Wang Zhe,Fu Junke,Diao Dongmei,Dang Chengxue. Pre-operative plasma D-dimer level may predict the poor prognosis within one year after the surgery for non-small cell lung cancer[J]. Chinese journal of lung cancer, 2011, 14(6): 534-537. DOI: 10.3779/j.issn.1009-3419.2011.06.10 | |
| Authors: | Wang Zhe Fu Junke Diao Dongmei Dang Chengxue |
| Affiliation: | Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. radishwang@yahoo.com |
| Abstract: | Background and objective Some operable non-small cell lung cancer (NSCLC) patients have poor prognosis shortly after the surgery. D-dimer (DD) is an independent prognosis factor of lung cancer, especially for inoperable patients. The aim of the study is to investigate whether the pre-operative plasma DD level could predict the poor prognosis shortly after the surgery in operable NSCLC patients. Methods The pre-operative plasma DD level of 56 newly diagnosed NSCLC patients without metastasis was examined. Al... |
| Keywords: | Lung neoplasms D-dimer Prognosis |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |