| 元安颗粒对慢性心力衰竭大鼠心肌组织黏附分子表达的影响 |
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| 引用本文： | 范建民,张稳,唐莹,廖若夷,雍苏南. 元安颗粒对慢性心力衰竭大鼠心肌组织黏附分子表达的影响[J]. 中国中医急症, 2013, 22(4): 563-565 |
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| 作者姓名： | 范建民 张稳 唐莹 廖若夷 雍苏南 |
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| 作者单位： | 湖南中医药大学第一附属医院,湖南长沙,410007 |
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| 基金项目： | 湖南中医药大学青年教师科研基金课题资助项目 |
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| 摘 要： | 目的探讨元安颗粒对慢性心力衰竭（CHF）大鼠心肌组织黏附分子表达的影响,研究其可能的作用机制。方法采用结扎WKY大鼠冠状动脉前降支法造成心肌梗死后形成CHF大鼠模型。观察心肌细胞病理变化。用ELISA法检测血清中心肌组织黏附分子表达情况。结果给药4周后,各组治疗前后比较,元安颗粒高、中、低剂量组与卡托普利组均能够降低血清中心肌组织黏附分子表达,差异有统计学意义,其中元安颗粒高剂量组疗效显著。结论元安颗粒是治疗CHF的有效方药。
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| 关 键 词： | 元安颗粒 慢性心力衰竭大鼠 心肌组织黏附分子 |
Effect of Yuan 'an Granule on Adhesion Molecule Expression in Myocardium of CHF Rats |
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| Affiliation: | FAN Jian-min,ZHANG Wen,TANG Ying,et al.(The First Hospital of Hunan University of Chinese Medicine,Hunan,Changsha,410007,China ) |
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| Abstract: | Objective： To investigate the effect of Yuan＇an Granule on adhesion molecule expression in CHF rats and to study the mechanism of Yuan＇an Granule on CHF.Methods： Through adhesion molecule expressions detected by ELISA method,the pathological changes in myocardium were observed in CHF rats models which were established by the ligating the left anterior descending coronary artery.Results： After 4 weeks,there were some obvious differences in the descending the expressions of adhesion molecule expressions of myocardium in the captopril group and the Yuan＇an Granule group.Conclusion： It is effective of Yuan＇an Granule in CHF. |
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| Keywords: | Yuan＇an Granule CHF rats Myocardium adhesion molecule |
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