Identification of CD56 and CD57 by flow cytometry in Ewing’s sarcoma or primitive neuroectodermal tumor |
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| Authors: | L J Gardner J M Polski R Fallon C H Dunphy |
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| Institution: | (1) Division of Hematopathology, Department of Pathology, Saint Louis University Health Sciences Center, St. Louis, Mo., USA, US;(2) Department of Hematology and Oncology, Cardinal Glennon Children’s Hospital, St. Louis, Mo., USA, US |
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| Abstract: | CD56 and CD57 are commonly considered as natural killer and neuroectodermal markers, but their expression has been identified
in a wide spectrum of neoplasms including some cases of Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET). We
report two cases of small, round blue cell tumor (SRBCT), in which flow cytometry immunophenotyping (FCI) detected strong
expression of CD56 and CD57 (one case). Immunohistochemical staining with Leu-19 and Leu-7 confirmed the FI results. Although
CD56 and CD57 expression is consistent with ES/PNET, it can be potentially misleading if results of FCI are interpreted in
the absence of other findings. These cases suggest the utility of FCI in undifferentiated SRBCT. The literature on CD56 and
CD57 expression in ES/PNET is reviewed and discussed.
Received: 5 January 1998 / Accepted: 19 February 1998 |
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| Keywords: | Ewing’ s sarcoma Primitive neuroectodermal tumor Flow cytometry Immunophenotyping NCAM Antigens |
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