某地区获得性耐药结核危险因素分析

[目的]了解某地区获得性耐药结核（ADR-TB）产生的主要危险因素,为有效地预防、干预和控制ADR-TB的发生提供依据。[方法]选取某省结核病防治所在2005年6月到2006年6月就诊的结核患者中的146例ADR-TB患者,按年龄和性别1︰1配对非耐药结核病患者。采用问卷调查耐药结核产生的危险因素,并进行条件logistic回归分析,用调整的比值比和可信区间评价危险因素与ADR-TB之间的联系。[结果]某地区ADR-TB产生的主要危险因素为复治患者、DOTS和依从性差,其调整的OR值及可信区间分别为2.117（1.526～3.264）、3.116（1.643～5.914）和1.929（1.263～2.966）。[结论]加强ADR-TB危险因素的研究,并有针对性的采取有效的预防和控制措施,对降低ADR-TB具有重要的意义。

STUDY ON RISK FACTORS FOR ACQUIRED DRUG RESISTANCE TUBERCULOSIS IN SOME PROVINCE

[Objective]To explore the main risk factors of acquired drug resistant tuberculosis(ADR-TB),and to provide evidence for its effective prevention,intervention and control.[Methods]A total of 146 cases of ADR-TB were selected from tuberculosis patients who sought for medical care in Institute of Tuberculosis Control and Prevention of Anhui Province from June,2005 to June,2006 and equally matched with controls without ADR-TB by age and gender.A questionnaire investigation about risk factors of ADR-TB was conducted among them,the obtained data were analyzed by conditional multivariate logistic regression and estimated with adjusted odds ratios(AOR)and confidence interval(CL).[Results]The main risk factors for ADR-TB in Anhui Province were recurrent patients,incomplete DOTS and poor compliance,and the adjusted OR and CI were 2.117(1.526-3.264),3.116(1.643-5.914)and 1.929(1.263-2.966),respectively.[Conclusions]Strengthening research on risk factors of ACR-TB and carrying out effective intervention measures are of great significance on reducing the incidence rate of ADR-TB.