| 萘呋胺酯草酸盐的合成工艺改进 |
| |
| 引用本文： | 蔡亚祥,徐建康,朱国良,徐明东,车大庆. 萘呋胺酯草酸盐的合成工艺改进[J]. 齐鲁药事, 2012, 31(6): 319-320 |
| |
| 作者姓名： | 蔡亚祥 徐建康 朱国良 徐明东 车大庆 |
| |
| 作者单位： | 浙江九洲药业股份有限公司,浙江,台州,318000 |
| |
| 摘 要： | 目的改进萘呋胺酯草酸盐的合成工艺。方法以糠醛和丙二酸二乙酯为起始原料经缩合、还原、烷基化、水解、脱羧和酯化等步骤制得萘呋胺酯草酸盐。结果目标化合物经1H-NMRI,R,MS谱确证,总收率在63.6%。结论改进后的工艺操作简便,成本低廉,有利于工业化生产
|
| 关 键 词： | 萘呋胺酯 缩合 还原 脱羧 酯化 |
Improvement on synthesis process of nafronyl oxalate |
| |
| CAI Ya-xiang , XU Jian-kang , ZHU Guo-liang , XU Ming-dong , CHE Da-qing. Improvement on synthesis process of nafronyl oxalate[J]. qilu pharmaceutical affairs, 2012, 31(6): 319-320 |
| |
| Authors: | CAI Ya-xiang XU Jian-kang ZHU Guo-liang XU Ming-dong CHE Da-qing |
| |
| Affiliation: | ( Zhejiang Jiuzhou Pharmaceutical Co. , Ltd. , Taizhou 318000, China ) |
| |
| Abstract: | Objective To improve the synthetic process of nafronyl oxalate. Methods Nafronyl oxalate was synthesized from furfural and diethyl malonate by condensation, reduction, alkylation, hydrolysis, decarboxylation and esterification. Results The structure of nafronyl oxalate was confirmed by 1H-NMR, IR, MS and the overall yield was 63.6%. Conclusion The im- proved process was convenient with low cost, and it was suitable for industrial production. |
| |
| Keywords: | Nafronyl Condensation Reduction Decarboxylation Esterification |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
