2型糖尿病患者趾臂指数与颈动脉及下肢动脉内中膜厚度的相关性研究

目的分析2型糖尿病(T2DM)患者趾臂指数(TBI)与外周动脉内中膜厚度(IMT)的相关性及TBI降低的危险因素。方法选择该院内分泌科住院的T2DM患者292例作为研究对象,分析其TBI与颈、股、腘动脉IMT的相关性及TBI降低的危险因素。结果 TBI降低组(TBI<0.7)与TBI正常组(TBI≥0.7)比较,年龄,DM病程,收缩压(SBP),颈、股、腘动脉IMT,DN患病人数差异均有统计学意义(P<0.05);TBI与颈、股、腘动脉IMT均呈负相关(r=-0.331、-0.288、-0.350,P<0.001);TBI降低的危险因素为年龄(OR=1.060、P<0.001、95%CI:1.027~1.095)、DM病程(OR=1.073、P=0.001、95%CI:1.027~1.121)、SBP(OR=1.021、P=0.018、95%CI:1.004~1.039)和吸烟史(OR=2.406、P=0.008、95%CI:1.251~4.626)。结论 T2DM患者TBI与颈、股、腘动脉IMT均呈负相关,年龄、糖尿病病程、SBP和吸烟史是TBI降低的危险因素。

The relationship between toe brachial index and carotid,lower extremity aterial intimal-medial thickness in patients with type 2 diabetes

Objective To evaluate to investigate the relationship between toe arm index(TBI)and arterial intima-media thickness(IMT),as well as the risk factors associated with the reducing of TBI among type 2 diabetes patients.Methods A total of 292 inpatients diagnosed for type 2 diabetes in the first Affiliated Hospital of Dalian Medical University were investigated.The risk factors associated with the reducing of TBI was evaluated by Logistic regression.The relationship between TBI and IMT was also evaluated.Results The patients with TBI<0.7 defined as low TBI group,whereas the patients with TBI≥0.7 defined as normal TBI group,there were significant difference on age,duration of diabetes,systolic blood pressure(SBP),carotid IMT,femoral arterial IMT,popliteal arterial IMT,rate of diabetic nephropathy between the two groups(P<0.05).According to Spearman correlation analysis,TBI negative correlated with carotid IMT,femoral arterial IMT and popliteal arterial IMT(r=-0.331,r=-0.288,r=-0.350,P<0.001).Risk factors of reducing of TBI were age(OR=1.060,P<0.001,95%CI:1.027-1.095),duration of diabetes(OR=1.073,P<0.001,95%CI:1.027-1.121),SBP(OR=1.021,P=0.018,95%CI:1.004-1.039)and smoking history(OR=2.406,P=0.008,95%CI:1.251-4.626).Conclusion In type 2 diabetes,TBI and carotid,femoral,popliteal arterial IMT negatively correlated,the risk factors of the reducing of TBI are age,duration of diabetes,SBP and smoking history.