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| 锰神经毒性机制研究进展 | |
| 引用本文： | 赵琳,李俊彦,陈静,朱晓娟,姜岳明. 锰神经毒性机制研究进展[J]. 中国药理学与毒理学杂志, 2021, 0(1): 58-64 |
| 作者姓名： | 赵琳 李俊彦 陈静 朱晓娟 姜岳明 |
| 作者单位： | 1.广西医科大学公共卫生学院卫生毒理学教研室 |
| 基金项目： | 国家自然科学基金(81773476);国家自然科学基金(81773476)。 |
| 摘 要： | 过量锰暴露可能会损害中枢神经系统,产生不可逆转的神经毒性,导致严重的神经退行性疾病.锰的神经毒性机制可能与转运稳态失调、氧化应激与线粒体损伤、自噬、蛋白质折叠错误、细胞凋亡、神经炎症有关,其中蛋白质错误折叠、线粒体损伤和神经炎症等又称锰神经毒性的3种主要损伤机制.本文对上述研究进展予以综述,以期为锰中毒防治提供科学依据... |
| 关 键 词： | 锰 神经毒性 神经炎症 |
Research progress in manganese neurotoxicity mechanism |
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| ZHAO Lin,LI Jun-yan,CHEN Jing,ZHU Xiao-juan,JIANG Yue-ming. Research progress in manganese neurotoxicity mechanism[J]. Chinese Journal of Pharmacology and Toxicology, 2021, 0(1): 58-64 | |
| Authors: | ZHAO Lin LI Jun-yan CHEN Jing ZHU Xiao-juan JIANG Yue-ming |
| Affiliation: | (Department of Hygienic Toxicology,School of Public Health,Guangxi Medical University,Nanning 530021,China) |
| Abstract: | Excessive manganese exposure may damage the central nervous system and produce irreversible neurotoxicity,resulting in severe neurodegenerative diseases.The mechanism of manganese neurotoxicity may be related to the dysregulation of transport homeostasis,oxidative stress and mitochondrial damage,autophagy,protein misfolding,cell apoptosis,and neuroinflammation,of which protein misfolding,mitochondrial damage,and neuroinflammation are also known as the"Mn Mechanistic Neurotoxic Triad".In this regard,this article provides a review of the scientific basis for the prevention and treatment of manganese poisoning. |
| Keywords: | manganese neurotoxicity neuroinflammation |
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