Rho GTP酶介导剪切力引起的血管内皮细胞通透性变化

血管内皮细胞通透性的变化与人类的许多疾病有关,如动脉粥样硬化、高血压、中风、炎症反应、肿瘤、糖尿病引起的视网膜病变和黄斑水肿等.剪切力是作用于血管内皮细胞的主要力学因素并对血管内皮细胞通透性起重要作用.Rho GTP酶家族是细胞信号转导通路中的一类重要蛋白,参与血管内皮细胞通透性的调控.研究表明,Rho GTP酶在介导剪切力引起血管内皮细胞通透性变化的过程中起重要的信号传导作用.就剪切力对血管内皮细胞通透性的影响以及Rho GTP酶在其分子机制上的作用进行综述.

Shear stress-regulated vascular endothelial permeability is mediated by Rho GTPases

Dysfunctions of vascular endothelial permeability are related to a number of human diseases such as atherosclerosis, high blood pressure, stroke, inflammation, cancer, diabetes-induced retinopathy, macular edema and so on. Shear stress is an important mechanical force that affects vascular endothelial cells. It plays a particular role in permeability regulation. Rho GTPases is a family of small G proteins which act as cell signal molecules. They are assumed to mediate the regulation of the permeability of vascular endothelial cells. In this paper review is given on how shear stress regulates the permeability of vascular endothehal cells as well as the in-fluence of Rho GTPases on the role in molecular mechanism. It is suggested that shear stress-regulated vascular endothelial permeability is mediated by Rho GTPases.