口腔颌面部横纹肌肉瘤及综合治疗

目的　探讨口腔颌面部横纹肌肉瘤的诊疗方法。方法　选择1981~2001年在四川大学华西口腔医院颌面外科治疗的横纹肌肉瘤患者共74例,按WHO(1972)的横纹肌肉瘤TNM分期和国际横纹肌肉瘤协作组(1988)对该瘤的临床分期进行分期,探讨横纹肌肉瘤病理分型,临床分期及治疗方法与预后的关系。结果　74例患者中,有 34例行扩大切除术,18例行局部切除术,术后所有患者均接受了不同剂量的放疗,另有22例患者因病变范围广或是儿童而只接受了放疗或者放、化疗联合治疗。随访病例的5年生存率随病期和治疗方案的不同而有显著差异, 肿瘤复发和手术切除边缘及临床分期明显相关。结论　采用扩大切除术加术后放疗对提高本病的治愈率,减少复发有明显效果;晚期或儿童患者采用局部切除联合放、化疗对于提高5年生存率有良好效果。

Rhabdomysarcoma and Combined Treatment in Oral and Maxillofacial Regions

Objective To study the treatment outcome of rhabdomysarcoma(RMS). Methods 74 cases of RMS with definite pathologic diagnosis treated in our department during the past 20 years were investigated. The relationship between the therapy and prognosis was analyzed.Results 52 cases among the 74 patients received different surgical treatment and post-operative radiotherapy. 22 cases received radiotherapy or chemoradiotherapy without surgical treatment. The survival rates demonstrated great differences depending on the different clinical stages and therapy.Conclusion The combined therapy including radiotherapy after surgical treatment may increase 5-year survival rate.