阿托伐他汀与氟伐他汀治疗高胆固醇血症的对比研究

目的　探讨阿托伐他汀 (立普妥 )与氟伐他汀 (来适可 )对高胆固醇血症病人疗效及安全性。方法　 10 0例高胆固醇血症随机分成阿托伐他汀组 5 0例和氟伐他汀组 5 0例 ,治疗 6周后观察比较。结果　阿托伐他汀及氟伐他汀均能明显降低TC、TG、LDL C水平 (P <0 0 1或P <0 0 5 ) ,阿托伐他汀降TC、TG、LDL C的作用强于氟伐他汀 (P <0 0 5 ) ,两药均能升高HDL C水平 (P <0 0 5 ) ,但两组比较未达到显著差异 (P >0 0 5 )。两药不良反应均比较小 ,耐受性好。结论　阿托伐他汀降TC、TG、LDL C的作用优于氟伐他汀 ,但升高HDL C水平相似 ,两药均有良好的安全性。

Comparative study of atorvastatin and fluvastatin in treatment of hypercholesterolemia

Objective To study the clinical efficacy and safety of atorvastatin(lipitor) and fluvastatin(lescol) on hypercholesterolemia.Methods One hundred patients with hypercholestrolemia were divided into atorvastatin group(n=50) and fluvastatin group(n=50).The lipid and safety was studied after treatment for 6 weeks.Results Atorvastatin and fluvastatin could significantly reduced the levels of TC,TG,LDL-C(P<0.01 or P<0.05).Atorvastatin was better than fluvastatin in reducing TC,TG,LDL-C(P<0.05).Both agents increased HDL-C(P<0.05) without significant difference between two groups.Both agents had little side-effect and good tolerance.Conclusion Atorvastatin is better than fluvastatin in reducing the levels of TC,TG,LDL-C,but is similary in increasing HDL-C.Both agents have good reliability.