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| 急性髓细胞白血病诱导治疗中大剂量柔红霉素应用疗效评价 | |
| 引用本文： | 祝彪,王晓冬,王春森,张晋琳. 急性髓细胞白血病诱导治疗中大剂量柔红霉素应用疗效评价[J]. 实用医院临床杂志, 2012, 9(1): 78-79 |
| 作者姓名： | 祝彪 王晓冬 王春森 张晋琳 |
| 作者单位： | 四川省医学科学院·四川省人民医院血液科,四川成都610072 |
| 摘 要： | 目的探讨大剂量柔红霉素在成人急性髓细胞白血病诱导治疗中的临床疗效。方法柔红霉素60 mg/m2,第1～3天,联合阿糖胞苷150 mg/m2,第1～7天,诱导治疗成人急性髓细胞白血病患者7例。结果 7例患者经第一次诱导化疗后4例达到完全缓解,2例未缓解,1例死亡,完全缓解率57%。结论大剂量柔红霉素[60～90 mg/（m2.d）]应用于国内成人急性髓细胞白血病诱导治疗疗效与常规剂量柔红霉素[45～50 mg/（m2.d）]相近,而血液学毒副反应大,无明显的心脏毒副反应增加。 |
| 关 键 词： | 柔红霉素 急性髓细胞白血病 成年人 |
Efficacy of large dose Daunorubicin in acute myeloid leukemia induction therapy |
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| ZHU Biao , WANG Xiao-dong , WANG Chun-sen , ZHANG Jin-lin. Efficacy of large dose Daunorubicin in acute myeloid leukemia induction therapy[J]. Practical Journal of Clinical Medicine, 2012, 9(1): 78-79 | |
| Authors: | ZHU Biao WANG Xiao-dong WANG Chun-sen ZHANG Jin-lin |
| Affiliation: | ( Department of Hematology, Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital, Chengdu 61007 2, China ) |
| Abstract: | Objective To evaluate the efficacy of large dose Daunorubicin in induction therapy for adult acute myeloid leukemia （AML）. Methods Seven cases of adult AML patients received induction therapy with Daunorubicin （60 mg/m2 q. d, 1 -3 d） plus Cytarabine （ 150 mg/m2 q. d, 1 - 7 d）. Results Complete remission （CR） was found in 4 patients after the first course of chemotherapy, while non-remission （NR） was found in 2 cases. The rest one died. The rate of CR was 57%. Conclusion The efficacy of large dose Daunorubicin （60 - 90 mg/m2. d） is close to that of standard dose Daunorubicin （45 - 50 mg/m2. d） in induction therapy for domestic adult AML with no notable increase of cardiac toxicity but greater hematological side effect. |
| Keywords: | Daunorubicin Acute myelocytic leukemia Adults |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |