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| 吡格列酮对糖尿病大鼠血管内皮功能的影响 | |
| 引用本文： | 楚能武,陈丽,章秋,李俊. 吡格列酮对糖尿病大鼠血管内皮功能的影响[J]. 安徽医药, 2009, 13(4): 365-367 |
| 作者姓名： | 楚能武 陈丽 章秋 李俊 |
| 作者单位： | 安徽医科大学第一附属医院内分泌科;安徽医科大学药学院,安徽,合肥,230023 |
| 摘 要： | 目的观察吡格列酮（Pioglitzone,PIO）对伴胰岛素抵抗的实验性2型糖尿病（Type 2 diabetes mellitus,T2DM）大鼠血管内皮功能、超微结构及炎症因子的影响。方法建立伴胰岛素抵抗的T2DM大鼠模型,随机分为DM组和PIO组,测定PIO治疗6周前后的各项指标,电镜下观察主动脉血管内皮细胞结构的变化。结果治疗6周后,与DM组相比,PIO组空腹血糖、糖化血红蛋白、胰岛素水平、胰岛素抵抗指数、胰岛素敏感指数及C反应蛋白均下降,血一氧化氮水平上升,差异均有显著性,但两组间血内皮素水平无显著差异。DM组主动脉血管内皮细胞线粒体肿胀,部分空泡变;PIO组仅发生轻度病理改变。结论PIO可以改善T2DM大鼠胰岛素抵抗,降低血糖,减轻主动脉形态学的损害,其机制可能与抗炎及改善血管内皮功能有关。 |
| 关 键 词： | 2型糖尿病 血管内皮功能 吡格列酮 |
Effects of pioglitazone on the vascular endothelial function of rat models with type 2 diabetes |
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| CHU Neng-wu,ZHANG Qiu,CHEN Li,LI Jun. Effects of pioglitazone on the vascular endothelial function of rat models with type 2 diabetes[J]. Anhui Medical and Pharmaceutical Journal, 2009, 13(4): 365-367 | |
| Authors: | CHU Neng-wu ZHANG Qiu CHEN Li LI Jun |
| Affiliation: | CHU Neng-wu,ZHANG Qiu,CHEN Li,LI Jun(The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China) |
| Abstract: | Aim To observe the effects of pioglitazone on the vascular endothelial function,the ultramicrostructure and inflammatory factor of rat models with type 2 diabetes accompanying insulin resistance.Methods Rat model with T2DM accompanying insulin resistance was established.They were divided into DM and PIO group randomly.The PIO group received administration of pioglitzone for 6 weeks,after that,some indexs are measured and heart arteriae aorta samples were observed by using light microscope and electron micro... |
| Keywords: | type 2 diabetes mellitus vascular endothelial function pioglitzone |
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