厄贝沙坦对老年高血压患者血管内皮功能的影响

目的探讨厄贝沙坦(irbesartan)对血管内皮功能的影响以及对老年高血压(EH)的疗效。方法64例老年EH患者,给予厄贝沙坦治疗4周,剂量150￣300mg/d,60例健康老年人作为对照组,测量两组治疗前后血压及血浆一氧化氮(nitricoxide,NO)和内皮素(endothelin,ET-1)水平。结果治疗前,EH组血浆NO浓度显著低于对照组(P<0.01),而血浆ET-1浓度明显高于对照组(P<0.01);EH组血压变化与血浆NO浓度呈负相关而与ET-1浓度呈正相关。经厄贝沙坦治疗4周后,收缩压及舒张压均明显下降(P<0.01),但心率变化不显著(P>0.05)。治疗总有效率为87.5%。治疗4周后血浆NO水平显著升高(P<0.05),且分期越高,血浆NO及ET-1浓度变化越显著。结论厄贝沙坦有显著的降压疗效,可以显著地修复和改善EH不良的血管内皮结构及功能。

Effect of Irbesartan on vascular endothelial function in elderly patients with essential hypertension

[Objective]To study the effects of irbesartan on the occurrence of essential hypertension(EH) and the change of the vascular endothelial function. A total of 64 patients with EH were treated with Irbesartan (150~300 mg), 60 health old people were selected as controlled group. The level of plasma endothelin-1 and NO, blood pressure were measured before and after the treatment of irbesartan. Before treatment with Irbesartan, the plasma NO level was significantly lower than that of the controlled group (P <0.01), and the level of ET-1 in plasma was significantly higher than that of the controlled group (P <0.01). But with the stages of EH increasing, the plasma level of ET-1 becames higher. The plasma level of NO showed negative relation with the stages of EH. After the treatment with irbesartan, the blood pressure were significantly lower than those before the treatment (P <0.01). The plasma level of NO was higher than that before the treatment (P <0.05). The level of ET-1 after treated decreased more than before (P <0.05). [Conclusion] The treatment with irbesartan can decrease the blood pressure and can improve the vascular endothelial constrcuction and function.