| Vogt-小柳原田综合征与HLA-DR4、DRw53相关的研究 |
| |
| 引用本文： | 黄祥坤,杨培增,周红颜,马翠萍,钟晖,陈玲,金浩丽,藉莉,谢楚芳,胡朝辉,陈盛强.Vogt-小柳原田综合征与HLA-DR4、DRw53相关的研究[J].眼视光学杂志,2000,2(2):99-100. |
| |
| 作者姓名： | 黄祥坤 杨培增 周红颜 马翠萍 钟晖 陈玲 金浩丽 藉莉 谢楚芳 胡朝辉 陈盛强 |
| |
| 作者单位： | 1. 中山医科大学中山眼科中心,广东,广州,510060
2. 广州医学院医学检验中心,广东,广州,510000 |
| |
| 基金项目： | 国家杰出青年基金项目!(39925034)，教育部优秀年轻教师基金，广东省自然科学基金项目!(980114)，广东省重点科技攻关项
目 |
| |
| 摘 要： | 目的 探讨ＨＬＡ－ＤＲ４、ＨＬＡ－ＤＲｗ５３抗原与Ｖｏｇｔ－小柳原田综合征的相关性。方法 用聚合酶链反应一系列引物对对６１例Ｖｏｇｔ－小柳原田综合征和１０２例健康人进行ＨＬＡ－ＤＲ４、ＨＬＡ－ＤＲｗ５３分型，结果：患者ＨＬＡ－ＤＲ４、ＨＬＡ－ＤＲｗ５３阳性率分别为４５．９０％和６２．２９％，正常对照组阳性率则分别为１４．７１％和３８．２４％，患者与正常对照组之间差异有显著性意义（Ｐ〈０．０５）。结
|
| 关 键 词： | Vogt小柳原田综合征 HLADR4 抗原 HLADRw53 |
Association
of Vogt-Koyanagi-Harada Syndrome with HLA-DR4 |
| |
| HUANG Xiangkun,YANG Peizeng,ZHOU Hongyan,et al..Association
of Vogt-Koyanagi-Harada Syndrome with HLA-DR4[J].Chinese Journal of Optometry & Ophthalmology,2000,2(2):99-100. |
| |
| Authors: | HUANG Xiangkun YANG Peizeng ZHOU Hongyan |
| |
| Institution: | HUANG Xiangkun,YANG Peizeng,ZHOU Hongyan,et al.Zhongshan Ophthalmic Center,Sun Yat-sen University of Medical Sciences,Guangzhou 510060 |
| |
| Abstract: | Objective:To investigate the association of Vogt-Koyanagi-Harada(VKH)Syndrome with HLA-DR4,HLA-DRw53 in Chinese patients.Methods:Polymerase chain reaction-sequence specific primer(PCR-SSP)was used for HLA-DR4,HLA-DRw53 typing in 61 patients with VKH syndrome and 102 healthy individuals.Results:The positive rate of both HLA-DR4(45.90%) and HLA-DRw53(62.29%) in patients with VKH syndrome was significantly higher than that in normal individuals(14.71% and 38.24% respectively).Conclusion:VKH syndrome is strongly associated with HLA-DR4 and HLA-DRw53 in Chinese patients. |
| |
| Keywords: | Vogt-Koyanagi-Harada Syndrome immunogenetics HLA-DR4 antigen HLA-DRw53 antigen comparative study |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
