谷胱甘肽硫转移酶M1与Tl基因缺失增加鼻咽癌易感性

目的在中国西南的广西壮族自治区的鼻咽癌高发区内研究谷胱甘肽硫转移酶M1与T1遗传多态性与鼻咽癌易感的相关性。方法病例与对照研究这些酶的遗传多态性(GSTM1和GSTT1零基因型),鼻咽癌总数为127例,对照207例。结果GSTM1和GSTT1零基因型的频数在NPC患者中较高,差异达统计学意义(P<0.001)。结论鼻咽癌是广西最常见癌症,GST酶与多种环境致癌物的解毒相关,同合子缺失GSTM1和GSTT1与数种癌相关,生鼻咽癌危险性已知与环境因素如吸烟和EB病毒感染相关联,我们的结果提示GSTM1和GSTT1缺失多态性与增加鼻咽癌易感性相关,若两种解毒酶基因同时缺失对鼻咽癌易感受性意义更重要。

Glutathione S-transferase M1 and T1 Gene Deletion Associated with Increased Susceptibility to Nasopharyngeal Carcinoma

Objective: To evaluate the association of Glutathione S-transferase (GST) M1 and T1 geneticpolymorphisms and susceptibility to nasopharyngeal carcinoma (NPC) in a high risk area of GuangxiZhuang Autonomous Region (province), Southwest of China. Methods: A case-control study was con-ducted to investigate the genetic polymorphisms of these enzymes (GSTM1 and GSTT1 null genotypes).A total of 127 NPC cases and 207 controls were recruited. Results: GSTM1 and GSTT1 null geno-type frequencies were higher among NPC patients at a level of statistical significance (P<0.005; P<0.001respectively), and both GSTM1 and GSTT1 null genotype were even more significant (P<0.001). Con-clusion: NPC is the most common cancer in Guangxi. GST enzymes are involved in the detoxificationof many environmental carcinogens. Homozygous deletions of GSTM1 and GSTT1 have been associatedwith several types of cancer. The risk to develop NPC has been associated with environmental factors suchas cigarette smoking and EB virus infection. The present results indicate that the GSTM1 and GSTT1deletion polymorphisms are associated with an increase risk of susceptibility to NPC, and both detoxificenzyme genes deletion is more important than a single gene deletion for the susceptibility to NPC.