| 丁胱亚磺酰亚胺对胶质瘤细胞谷光甘肽及放射增敏作用的实验研究 |
| |
| 引用本文： | 仝海波,金一尊,江澄川,严敏芬,唐镇生,徐立明.丁胱亚磺酰亚胺对胶质瘤细胞谷光甘肽及放射增敏作用的实验研究[J].中华放射医学与防护杂志,1998,18(6):399-402. |
| |
| 作者姓名： | 仝海波 金一尊 江澄川 严敏芬 唐镇生 徐立明 |
| |
| 作者单位： | 上海医科大学华山医院神经外科，上海放射医学研究所 |
| |
| 摘 要： | 研究巯基修饰剂ＢＳＯ对胶质瘤细胞ＧＳＨ含量的修饰作用和放射增敏作用。方法利用Ｔｉｅｔｚｅ还原酶法观察ＢＳＯ对体外培养的胶质瘤细胞株及裸小鼠移植瘤模型胶质瘤细胞ＧＳＨ的作用。利用ＭＴＴ法观察ＢＳＯ对胶质瘤细胞放射敏感性的影响。结果经ＢＳＯ作用后胶质瘤细胞的ＧＳＨ含量显著下降，放射敏感性增加。结论无论是离体还是整体用药，ＢＳＯ均能降低胶质瘤细胞的ＧＳＨ含量。ＢＳＯ对胶质瘤细胞有放射增敏作用。
|
| 关 键 词： | 胶质瘤 丁胱亚磺酰亚胺 谷胱甘肽 放射敏感性 |
| 收稿时间： | 1997/7/18 0:00:00 |
| 修稿时间： | 1997/10/29 0:00:00 |
Effect of buthionine sulfoximine on glutathione content and radiation sensitivity of glioma cells. |
| |
| Tong Haibao,Jin Yizun,Jiang Chengchuan.Effect of buthionine sulfoximine on glutathione content and radiation sensitivity of glioma cells.[J].Chinese Journal of Radiological Medicine and Protection,1998,18(6):399-402. |
| |
| Authors: | Tong Haibao Jin Yizun Jiang Chengchuan |
| |
| Institution: | Tong Haibao,Jin Yizun,Jiang Chengchuan,et al.Institute of Neurology,Shanghai Medical University,Shanghai 200040,China.Institut of Radiation Medicine,Shanghai Medical University,Shanghai 200032,China |
| |
| Abstract: | Objective To observe the effect of buthionine sulfoximine (BSO) on glutathione (GSH) content and radiosensitvity of glioma cells. Methods\ Using Tietze method to detect BSO on cultured glioma cell line and glioma bearing nude mice and MTT method to observe the effect of BSO on radiosensitivity of glioma cells.Results\ BSO depleted the GSH content of glioma cells effectively and increased the radiation sensitivity. Conclusion\ Both under hypoxic and aerobic conditions BSO can deplete intracellular GSH and increase the radiation sensitivity of glioma cell. |
| |
| Keywords: | Glioma Buthionine salfoximine Glutathione Radiation sensitivity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中华放射医学与防护杂志》浏览原始摘要信息 |
| 点击此处可从《中华放射医学与防护杂志》下载免费的PDF全文 |
