传染性单核细胞增多症与皮肤黏膜淋巴结综合征的实验室检测对比分析

目的　分析传染性单核细胞增多症 (IM)和皮肤黏膜淋巴结综合征 (MCLS)的实验室检测结果 ,并对比分析 ,以明确二者的鉴别诊断要点 ,指导治疗。方法　收集我院近 10年住院IM患儿 2 2 5例 ,MCLS患儿 2 80例。实验室指标包括 :EB病毒 (EBV)抗体、嗜异凝集试验、外周血白细胞总数及分类、异形淋巴细胞、血小板计数等进行对比分析。结果　IM及MCLS患儿EBV抗体阳性率均高 ,无显著差异。嗜异凝集试验及异形淋巴细胞检查 ,阳性率差异甚大 ,IM患儿中可见明显增高。外周血白细胞总数均增高 ,MCLS白细胞分类以中性粒细胞升高更明显 ,而IM则以淋巴细胞升高明显 ;而血小板计数则以MCLS增高明显 ,且当白细胞总数趋于正常时血小板持续升高。结论　IM及MCLS病因似与EBV感染有连带关系 ,在实验室检查中各有特点 ,掌握其鉴别诊断要点 ,对早期明确诊断 ,指导治疗有重要意义

Comparison of laboratory detection between infectious mononucleosis and mucocutaneous lymphnode syndrome

Objective To analyze the laboratory detection findings in infectious mononucleosis(IM) and mucocutaneous lymphnode syndrome(MCLS)and find the main points of the differential diagnosis and direct the treatment. Methods Five hundreds and twenty-five children were in-patient department over these past 10 years .These patients were divided into 2 groups,IM group (225 patients) and MCLS group(280 patients). EB-virus antibody,Paul-Bunnell test,the circumference blood numeration ,classification of leucocytes,the numeration of atypical lymphocytes were detected and compared,as well as blood platelet of these patients.Results The positive rate of EB-virus antibody in IM and MCLS were high, and had no discrepancy. However, the positive rate of Paul-Bunnell test and numeration of atypical lymphocyte in IM group were significantly higher than those in MCLS group. The total circumference blood leucocyte numeration of the groups increased,but the numeration neutrophil increased significantly in MCLS group, the rising numeration of lymphocyte in IM; the blood platelet numeration was elevated significantly in MCLS group and continued when the total circumference blood leucocyte numeration tended normally.Conclusions The causes of IM and MCLS are related to the infection of EB-virus. The laboratory characteristics of IM and MCLS are different,understanding the main points of the differential diagnosis contributes to the clear diagnose and early treatment.